Huang Hao, Yang Xing-Jiu, Gao Ran
Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College,Beijing 100021,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Dec 20;38(6):739-745. doi: 10.3881/j.issn.1000-503X.2016.06.020.
Gastric cancer is one of the most common human malignancies and the third cause of death from cancer in China and worldwide. Chemotherapy is still one of the major treatment options for advanced gastric cancer. However,the efficacy of chemotherapy for gastric cancer remains poor due to its insensitivity and the development of multidrug resistance (MDR). While many molecules and mechanisms have been found to be associated with the development of gastric cancer MDR,the specific mechanisms remains unclear. In our current article,we reviews the identification of MDR-related molecules and mechanisms,with an attempt to a better understand the specific mechanisms of gastric cancer MDR and thus provide new insights into the fight against gastric cancer MDR.
胃癌是人类最常见的恶性肿瘤之一，在中国和全球范围内都是癌症死亡的第三大原因。化疗仍然是晚期胃癌的主要治疗选择之一。然而，由于胃癌对化疗不敏感以及多药耐药（MDR）的出现，化疗对胃癌的疗效仍然很差。虽然已经发现许多分子和机制与胃癌MDR的发生有关，但具体机制仍不清楚。在我们当前的文章中，我们综述了MDR相关分子和机制的鉴定，试图更好地理解胃癌MDR的具体机制，从而为对抗胃癌MDR提供新的见解。
