Crawford Natalie M, Pritchard David A, Herring Amy H, Steiner Anne Z
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.
Fertil Steril. 2017 Mar;107(3):749-755. doi: 10.1016/j.fertnstert.2016.11.022. Epub 2017 Jan 5.
To evaluate the impact of a short luteal phase on fecundity.
Prospective time-to-pregnancy cohort study.
Not applicable.
PATIENT(S): Women trying to conceive, ages 30-44 years, without known infertility.
INTERVENTION(S): Daily diaries, ovulation prediction testing, standardized pregnancy testing.
MAIN OUTCOME MEASURE(S): Subsequent cycle fecundity.
RESULT(S): Included in the analysis were 1,635 cycles from 284 women. A short luteal phase (≤11 days including the day of ovulation) occurred in 18% of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy in the subsequent cycle immediately following the short luteal phase compared with women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months there was no significant difference in cumulative probability of pregnancy.
CONCLUSION(S): Although an isolated cycle with a short luteal phase may negatively affect short-term fertility, incidence of infertility at 12 months was not significantly higher among these women.
NCT01028365.
评估黄体期短对生育力的影响。
前瞻性妊娠时间队列研究。
不适用。
年龄在30 - 44岁、试图受孕且无已知不孕症的女性。
每日记录、排卵预测测试、标准化妊娠测试。
后续周期的生育力。
纳入分析的有来自284名女性的1635个周期。在观察到的周期中，18%出现了短黄体期（包括排卵日在内≤11天）。黄体期平均长度为14天。短黄体期的女性吸烟者显著更多。在调整年龄后，与无短黄体期的女性相比，短黄体期的女性在短黄体期后的随后一个周期怀孕几率为其0.82倍。在首次观察周期中黄体期短的女性在尝试怀孕的前6个月后生育力显著较低，但在12个月时累积怀孕概率无显著差异。
尽管孤立的短黄体期周期可能对短期生育力有负面影响，但这些女性在12个月时不孕症发生率并未显著更高。
NCT01028365。
