Alvergne Alexandra, Kountourides Gabriella, Argentieri M Austin, Agyen Lisa, Rogers Natalie, Knight Dawn, Sharp Gemma C, Maybin Jacqueline A, Olszewska Zuzanna
ISEM, Montpellier University, CNRS, IRD, Montpellier, France.
School of Anthropology and Museum Ethnography, Oxford, UK.
iScience. 2023 Apr 21;26(4):106401. doi: 10.1016/j.isci.2023.106401. Epub 2023 Mar 15.
There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of vaccination compared to SARS-CoV-2 infection. Our objectives were to test potential risk factors for reporting menstrual cycle changes following COVID-19 vaccination and to compare menstrual parameters following COVID-19 vaccination and COVID-19 disease. We performed a secondary analysis of a retrospective online survey conducted in the UK in March 2021. In pre-menopausal vaccinated participants (n = 4,989), 18% reported menstrual cycle changes after their first COVID-19 vaccine injection. The prevalence of reporting any menstrual changes was higher for women who smoke, have a history of COVID-19 disease, or are not using estradiol-containing contraceptives. In a second sample including both vaccinated and unvaccinated participants (n = 12,579), COVID-19 vaccination alone was not associated with abnormal menstrual cycle parameters, while a history of COVID-19 disease was associated with an increased risk of reporting heavier bleeding, "missed" periods, and inter-menstrual bleeding.
与感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）相比，新冠病毒疫苗接种是否会导致月经紊乱引发了公众越来越多的关注。我们的目标是检测新冠病毒疫苗接种后报告月经周期变化的潜在风险因素，并比较新冠病毒疫苗接种和感染新冠病毒疾病后的月经参数。我们对2021年3月在英国进行的一项回顾性在线调查进行了二次分析。在绝经前接种疫苗的参与者（n = 4989）中，18%报告在首次接种新冠病毒疫苗后月经周期发生了变化。吸烟、有新冠病毒疾病史或未使用含雌二醇避孕药的女性报告任何月经变化的患病率更高。在第二个样本中，包括接种疫苗和未接种疫苗的参与者（n = 12579），仅新冠病毒疫苗接种与月经周期参数异常无关，而新冠病毒疾病史与报告月经量增多、“月经推迟”和经间期出血的风险增加有关。
