Moorhouse K G, Hutson D H, Dodds P F
Department of Biochemistry and Biological Sciences, Wye College, University of London, Ashford, Kent, England.
FEBS Lett. 1989 Oct 9;256(1-2):43-6. doi: 10.1016/0014-5793(89)81714-4.
A number of xenobiotic carboxylic acids, including 3-phenoxybenzoic acid (3PBA), have been shown to form 'hybrid' di- and tri-acylglycerols both in vivo and in vitro. Experiments were carried out to test the hypothesis that naturally occurring xenobiotic diacylglycerols may stimulate protein kinase C. The activity of protein kinase C was measured in the presence of different diacylglycerols. 1-Acyl-2-(3PBA)-sn-glycerol but not 1,2-di-3PBA-sn-glycerol stimulated protein kinase C, but less effectively than either dioleoylglycerol or phorbol 12-myristate 13-acetate. The xenobiotic diacylglycerols were also more resistant to lipolysis. The possibility exists therefore that some xenobiotic diacylglycerols may behave, like phorbol diesters, as tumour promoters.
包括3-苯氧基苯甲酸（3PBA）在内的多种外源性羧酸已被证明在体内和体外均可形成“混合”二酰基甘油和三酰基甘油。开展实验以检验以下假设：天然存在的外源性二酰基甘油可能会刺激蛋白激酶C。在不同二酰基甘油存在的情况下测定蛋白激酶C的活性。1-酰基-2-（3PBA）-sn-甘油而非1,2-二-3PBA-sn-甘油可刺激蛋白激酶C，但效果不如二油酰甘油或佛波醇12-肉豆蔻酸酯13-乙酸酯。外源性二酰基甘油对脂解作用也更具抗性。因此，某些外源性二酰基甘油有可能像佛波醇二酯一样发挥肿瘤促进剂的作用。
