佛波酯、二酰基甘油、Ca2+和激素对分离的大鼠肝细胞中糖原磷酸化酶相互转化的控制。
Control of glycogen phosphorylase interconversion by phorbol esters, diacylglycerols, Ca2+ and hormones in isolated rat hepatocytes.
作者信息
van de Werve G, Proietto J, Jeanrenaud B
出版信息
Biochem J. 1985 Nov 1;231(3):511-6. doi: 10.1042/bj2310511.
Abstract
In isolated rat hepatocytes: phosphorylase activation by the ionophore A23187 was enhanced in the presence of tumour-promoting phorbol esters and 1,2- (but not 1,3-) diacylglycerols (dioleoyl- and oleoylacetyl-glycerol), with a similar dose-dependency; the activation of phosphorylase by phenylephrine (1 microM) (but not by vasopressin or glucagon) was inhibited both by tumour-promoting phorbol esters and diacylglycerols, but with a different dose-dependency: complete inhibition was achieved with concentrations of phorbol esters two orders of magnitude lower than those of diacylglycerol; binding of the alpha 1-adrenergic antagonist [3H]prazosin and its displacement by unlabelled prazosin was not significantly affected in the presence of the phorbol esters. The possible involvement of protein kinase C in the control of phosphorylase interconversion is discussed.
摘要
在分离的大鼠肝细胞中
在促肿瘤佛波酯和1,2 -（而非1,3 -）二酰基甘油（二油酰甘油和油酰乙酰甘油）存在的情况下，离子载体A23187对磷酸化酶的激活作用增强，且具有相似的剂量依赖性；促肿瘤佛波酯和二酰基甘油均抑制苯肾上腺素（1微摩尔）（而非血管加压素或胰高血糖素）对磷酸化酶的激活作用，但剂量依赖性不同：达到完全抑制所需的佛波酯浓度比二酰基甘油低两个数量级；在佛波酯存在的情况下，α1 -肾上腺素能拮抗剂[3H]哌唑嗪的结合及其被未标记哌唑嗪的取代未受到显著影响。文中讨论了蛋白激酶C可能参与磷酸化酶相互转化调控的情况。
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本文引用的文献
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
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