Harenski Carla L, Brook Michael, Kosson David S, Bustillo Juan R, Harenski Keith A, Caldwell Michael F, Van Rybroek Gregory J, Koenigs Michael, Decety Jean, Thornton David M, Calhoun Vince D, Kiehl Kent A
The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
Soc Cogn Affect Neurosci. 2017 Jan 1;12(1):70-80. doi: 10.1093/scan/nsw164.
Relative to the general population, individuals with psychotic disorders have a higher risk of suicide. Suicide risk is also elevated in criminal offenders. Thus, psychotic-disordered individuals with antisocial tendencies may form an especially high-risk group. We built upon prior risk analyses by examining whether neurobehavioral correlates of social cognition were associated with suicidal behavior in criminal offenders with psychotic disorders. We assessed empathic accuracy and brain structure in four groups: (i) incarcerated offenders with psychotic disorders and past suicide attempts, (ii) incarcerated offenders with psychotic disorders and no suicide attempts, (iii) incarcerated offenders without psychotic disorders and (iv) community non-offenders without psychotic disorders. Established suicide risk variables were examined along with empathic accuracy and gray matter in brain regions implicated in social cognition. Relative to the other groups, offenders with psychotic disorders and suicide attempts had lower empathic accuracy and smaller temporal pole volumes. Empathic accuracy and temporal pole volumes were significantly associated with suicide attempts independent of other risk variables. The results indicate that brain and behavioral correlates of social cognition may add incremental value to models of suicide risk.
相对于普通人群，患有精神障碍的个体自杀风险更高。刑事罪犯的自杀风险也有所升高。因此，具有反社会倾向的精神障碍个体可能构成一个特别高风险的群体。我们在先前风险分析的基础上，研究了社会认知的神经行为相关性是否与患有精神障碍的刑事罪犯的自杀行为有关。我们评估了四组人群的共情准确性和脑结构：（i）患有精神障碍且有过自杀未遂经历的在押罪犯，（ii）患有精神障碍但无自杀未遂经历的在押罪犯，（iii）无精神障碍的在押罪犯，以及（iv）无精神障碍的社区非罪犯。我们检查了既定的自杀风险变量以及与社会认知相关的脑区中的共情准确性和灰质。相对于其他组，患有精神障碍且有自杀未遂经历的罪犯共情准确性较低，颞极体积较小。共情准确性和颞极体积与自杀未遂显著相关，独立于其他风险变量。结果表明，社会认知的脑和行为相关性可能为自杀风险模型增加额外价值。
