Sarkinaite Milda, Gleizniene Rymante, Adomaitiene Virginija, Dambrauskiene Kristina, Raskauskiene Nijole, Steibliene Vesta
Department of Radiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Psychiatry Clinic of Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Diagnostics (Basel). 2021 Mar 10;11(3):488. doi: 10.3390/diagnostics11030488.
Structural brain changes are found in suicide attempters and in patients with mental disorders. It remains unclear whether the suicidal behaviors are related to atrophy of brain regions and how the morphology of specific brain areas is changing with each suicide attempt. The sample consisted of 56 patients hospitalized after first suicide attempt (first SA) ( = 29), more than one suicide attempt (SA > 1) ( = 27) and 54 healthy controls (HC). Brain volume was measured using FreeSurfer 6.0 automatic segmentation technique. In comparison to HC, patients with first SA had significantly lower cortical thickness of the superior and rostral middle frontal areas, the inferior, middle and superior temporal areas of the left hemisphere and superior frontal area of the right hemisphere. In comparison to HC, patients after SA > 1 had a significantly lower cortical thickness in ten areas of frontal cortex of the left hemisphere and seven areas of the right hemisphere. The comparison of hippocampus volume showed a significantly lower mean volume of left and right parts in patients with SA > 1, but not in patients with first SA. The atrophy of frontal, temporal cortex and hippocampus parts was significantly higher in repeated suicide attempters than in patients with first suicide attempt.
在自杀未遂者和精神障碍患者中发现了大脑结构变化。目前尚不清楚自杀行为是否与脑区萎缩有关，以及特定脑区的形态如何随着每次自杀未遂而发生变化。样本包括56例首次自杀未遂（首次SA）后住院的患者（n = 29）、多次自杀未遂（SA > 1）的患者（n = 27）和54名健康对照者（HC）。使用FreeSurfer 6.0自动分割技术测量脑容量。与HC相比，首次SA患者的左半球上额和额中回前部、颞下、颞中及颞上区域以及右半球额上区域的皮质厚度显著降低。与HC相比，SA > 1患者的左半球额叶皮质十个区域和右半球七个区域的皮质厚度显著降低。海马体体积比较显示，SA > 1患者的左右部分平均体积显著低于首次SA患者。反复自杀未遂者的额叶、颞叶皮质和海马体部分的萎缩明显高于首次自杀未遂患者。
