Christudas Mini Johnson, Gupta Balaji Sathyanarayana, Undela Krishna, Isaac Noel M, Ram Dushad, Ramesh Madhan
Department of Pharmacy Practice, JSS College of Pharmacy, Mysuru, Karnataka, India.
Department of Psychiatry, JSS Medical College & Hospital, Jagadguru Sri Shivarathreeshwara University, Mysuru, Karnataka, India.
Indian J Pharmacol. 2016 Nov-Dec;48(6):701-705. doi: 10.4103/0253-7613.194858.
To investigate the impact of pharmacophilia and pharmacophobia on medication adherence among patients with psychiatric disorders.
A cross-sectional, observational study was conducted in the Department of Psychiatry over a period of 2 months. Patients above 18 years of age with a psychiatric diagnosis as per the International Classification of Diseases 10 and receiving at least one psychotropic medication (any medication capable of affecting the mind, emotions, and behavior) for >1 month were enrolled in the study. Patients who were critically ill, on magico-religious treatment (beliefs prevalent in a particular culture concerning various supernatural influences operating in the environment), diagnosis of dementia, or mental retardation and patients from whom reliable history of illness cannot be obtained were excluded from the study. Drug attitude inventory scale was used to classify patients into pharmacophilic and pharmacophobic groups. Medication adherence rating scale was used to identify the extent of medication adherence.
Among 176 patients included, 110 were found to be pharmacophilic and 54 were pharmacophobic. The number of hospitalizations ( < 0.03) and adverse drug reactions ( < 0.001) were found to be higher in pharmacophobic group as compared to pharmacophilic group. Antipsychotics were found to be most commonly prescribed medications among pharmacophobic group ( < 0.001). In this study, patients who had pharmacophilia were found to be have higher adherence score (mean score: 6.98) than patients with pharmacophobia (mean score: 2.9), with P< 0.001.
This study concluded that pharmacophobia toward psychopharmacological agents can significantly reduce the medication adherence among patients with psychiatric disorders.
探讨药物偏好和药物恐惧对精神疾病患者用药依从性的影响。
在精神科进行了一项为期2个月的横断面观察性研究。纳入年龄在18岁以上、根据国际疾病分类第10版诊断为精神疾病且接受至少一种精神药物（任何能够影响思维、情绪和行为的药物）治疗超过1个月的患者。病情危重、接受魔法宗教治疗（特定文化中关于环境中各种超自然影响的普遍信仰）、诊断为痴呆或智力障碍的患者以及无法获得可靠疾病史的患者被排除在研究之外。使用药物态度量表将患者分为药物偏好组和药物恐惧组。使用用药依从性评定量表来确定用药依从性的程度。
在纳入的176例患者中，发现110例为药物偏好型，54例为药物恐惧型。与药物偏好组相比，药物恐惧组的住院次数（<0.03）和药物不良反应（<0.001）更高。在药物恐惧组中，抗精神病药物被发现是最常用的药物（<0.001）。在本研究中，发现药物偏好型患者的依从性得分（平均得分：6.98）高于药物恐惧型患者（平均得分：2.9），P<0.001。
本研究得出结论，对精神药物的药物恐惧会显著降低精神疾病患者的用药依从性。
