吸烟对卵泡液的致突变性有影响吗？

Is there influence of smoking on the mutagenicity of follicular fluid?

作者信息

Bos R P, van Heijst C H, Hollanders H M, Theuws J L, Thijssen R F, Eskes T K

机构信息

St. Radboud University Hospital, Nijmegen, The Netherlands.

出版信息

Fertil Steril. 1989 Nov;52(5):774-7. doi: 10.1016/s0015-0282(16)61030-0.

DOI:10.1016/s0015-0282(16)61030-0

PMID:2806619

Abstract

The mutagenicity of follicular fluid was examined in 24 patients, 12 smoking and 12 nonsmoking, who were treated in an in vitro fertilization program. The Salmonella microsome assay was used. It was found that the mutagenicity of follicular fluid was not influenced by the number of cigarettes smoked. Urine samples of smoking in vitro fertilization (IVF) patients however showed a dose-dependent elevation of the mutagenicity.

摘要

对24名接受体外受精治疗的患者（12名吸烟者和12名非吸烟者）的卵泡液致突变性进行了检测。采用沙门氏菌微粒体试验。结果发现，卵泡液的致突变性不受吸烟数量的影响。然而，体外受精（IVF）吸烟患者的尿液样本显示其致突变性呈剂量依赖性升高。