Colcombet Jean, Sözen Cécile, Hirt Heribert
Institute of Plant Sciences Paris-Saclay, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université Paris-Sud, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, Université Paris-Saclay Orsay, France.
Center for Desert Agriculture, King Abdullah University of Science and Technology Thuwal, Saudi Arabia.
Front Plant Sci. 2016 Dec 22;7:1941. doi: 10.3389/fpls.2016.01941. eCollection 2016.
Since its first description in 1995 and functional characterization 12 years later, plant MKK3-type MAP2Ks have emerged as important integrators in plant signaling. Although they have received less attention than the canonical stress-activated mitogen-activated protein kinases (MAPKs), several recent publications shed light on their important roles in plant adaptation to environmental conditions. Nevertheless, the MKK3-related literature is complicated. This review summarizes the current knowledge and discrepancies on MKK3 MAPK modules in plants and highlights the singular role of MKK3 in green plants. In the light of the latest data, we hypothesize a general model that all clade-III MAP3Ks converge on MKK3 and C-group MAPKs, thereby defining a set of novel MAPK modules which are activated by stresses and internal signals through the transcriptional regulation of genes.
自1995年首次被描述并于12年后进行功能表征以来，植物MKK3型促分裂原活化蛋白激酶激酶（MAP2Ks）已成为植物信号传导中的重要整合因子。尽管它们受到的关注少于典型的应激激活丝裂原活化蛋白激酶（MAPKs），但最近的几篇出版物揭示了它们在植物适应环境条件中的重要作用。然而，与MKK3相关的文献较为复杂。本综述总结了目前关于植物中MKK3 MAPK模块的知识和差异，并强调了MKK3在绿色植物中的独特作用。根据最新数据，我们假设了一个通用模型，即所有III类促分裂原活化蛋白激酶激酶（MAP3Ks）都汇聚于MKK3和C组促分裂原活化蛋白激酶（MAPKs），从而定义了一组新的MAPK模块，这些模块通过基因的转录调控被应激和内部信号激活。
