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Editing genetics, stem cells are prophetic, what's the best way to model cells of diabetics?

作者信息

Scavuzzo Marissa A, Borowiak Malgorzata

机构信息

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA;; Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Stem Cell Investig. 2016 Nov 15;3:81. doi: 10.21037/sci.2016.11.02. eCollection 2016.

DOI:10.21037/sci.2016.11.02
PMID:28066783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5182207/
Abstract
摘要

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本文引用的文献

1
Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.解决血管生成素样蛋白8在β细胞增殖方面的矛盾发现:解决β细胞营养因子争议的协作方法
PLoS One. 2016 Jul 13;11(7):e0159276. doi: 10.1371/journal.pone.0159276. eCollection 2016.
2
Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes.人类多能干细胞中谱系决定因子的基因组编辑揭示胰腺发育和糖尿病的机制
Cell Stem Cell. 2016 Jun 2;18(6):755-768. doi: 10.1016/j.stem.2016.03.015. Epub 2016 Apr 28.
3
The iCRISPR platform for rapid genome editing in human pluripotent stem cells.用于人类多能干细胞快速基因组编辑的iCRISPR平台。
Methods Enzymol. 2014;546:215-50. doi: 10.1016/B978-0-12-801185-0.00011-8.
4
Generation of functional human pancreatic β cells in vitro.体外生成功能性人胰腺β细胞。
Cell. 2014 Oct 9;159(2):428-39. doi: 10.1016/j.cell.2014.09.040.
5
Neurogenin 3 is important but not essential for pancreatic islet development in humans.神经生成素3对人类胰岛发育很重要,但并非必不可少。
Diabetologia. 2014 Nov;57(11):2421-4. doi: 10.1007/s00125-014-3349-y. Epub 2014 Aug 14.
6
An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.一种用于在人类多能干细胞中进行快速、多重且可诱导的基因组编辑的iCRISPR平台。
Cell Stem Cell. 2014 Aug 7;15(2):215-226. doi: 10.1016/j.stem.2014.05.018. Epub 2014 Jun 12.
7
Pdx1 maintains β cell identity and function by repressing an α cell program.胰腺十二指肠同源盒基因1通过抑制α细胞程序来维持β细胞的特性和功能。
Cell Metab. 2014 Feb 4;19(2):259-71. doi: 10.1016/j.cmet.2013.12.002.
8
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.分析对小鼠胰腺发育至关重要的转录因子,确定 NKX2-2 和 MNX1 突变是导致人类新生儿糖尿病的原因。
Cell Metab. 2014 Jan 7;19(1):146-54. doi: 10.1016/j.cmet.2013.11.021.
9
Pancreas organogenesis: from lineage determination to morphogenesis.胰腺器官发生:从谱系决定到形态发生。
Annu Rev Cell Dev Biol. 2013;29:81-105. doi: 10.1146/annurev-cellbio-101512-122405. Epub 2013 Jul 31.
10
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.胚胎干细胞来源的内胚层细胞群体的功能评估揭示了 Nodal 和 Activin A 指导的分化之间的差异。
Development. 2013 Feb 1;140(3):675-86. doi: 10.1242/dev.085431.