Hesse Swen, Becker Georg-Alexander, Rullmann Michael, Bresch Anke, Luthardt Julia, Hankir Mohammed K, Zientek Franziska, Reißig Georg, Patt Marianne, Arelin Katrin, Lobsien Donald, Müller Ulrich, Baldofski S, Meyer Philipp M, Blüher Matthias, Fasshauer Mathias, Fenske Wiebke K, Stumvoll Michael, Hilbert Anja, Ding Yu-Shin, Sabri Osama
Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Integrated Treatment and Research Centre (IFB) Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany.
Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1056-1064. doi: 10.1007/s00259-016-3590-3. Epub 2017 Jan 9.
The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate.
We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m) healthy controls.
Overall, we found no significant differences in binding potential (BP) values between obese and non-obese individuals in the investigated brain regions, including the NAT-rich thalamus (0.40 ± 0.14 vs. 0.41 ± 0.18; p = 0.84) though additional discriminant analysis correctly identified individual group affiliation based on regional BP in all but one (control) case. Furthermore, inter-regional correlation analyses indicated different BP patterns between both groups but this did not survive testing for multiple comparions.
Our data do not find an overall involvement of NAT changes in human obesity. However, preliminary secondary findings of distinct regional and associative patterns warrant further investigation.
脑去甲肾上腺素（NA）系统在能量平衡的中枢神经控制中起重要作用，因此与肥胖的发病机制有关。这种神经递质调节导致肥胖和暴饮暴食的具体过程仍存在争议。
我们通过正电子发射断层扫描（PET）和S,S-[C]O-甲基瑞波西汀（MRB），在20名受试者中测试了肥胖时体内NA转运体（NAT）可用性是否发生变化的假设，这20名受试者包括10名高度肥胖（体重指数BMI>35kg/m）、代谢健康、无抑郁的个体和10名非肥胖（BMI<30kg/m）的健康对照。
总体而言，我们发现在包括富含NAT的丘脑在内的研究脑区中，肥胖个体与非肥胖个体之间的结合潜能（BP）值无显著差异（0.40±0.14对0.41±0.18；p=0.84），尽管额外的判别分析在除1例（对照）外的所有病例中，根据区域BP正确识别了个体所属组别。此外，区域间相关性分析表明两组之间的BP模式不同，但在多重比较检验中未通过。
我们的数据未发现NAT变化在人类肥胖中普遍存在。然而，不同区域和关联模式的初步次要发现值得进一步研究。
