从苦豆子种子中分离得到的 4 种具有抗乙肝病毒活性的苦参碱类生物碱。
Four Matrine-Based Alkaloids with Antiviral Activities against HBV from the Seeds of Sophora alopecuroides.
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632, People's Republic of China.
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University , Guangzhou 510632, People's Republic of China.
出版信息
Org Lett. 2017 Jan 20;19(2):424-427. doi: 10.1021/acs.orglett.6b03685. Epub 2017 Jan 9.
Four novel matrine-based alkaloids (1-4) were isolated from the seeds of Sophora alopecuroides. Compounds 1 and 2 possess unprecedented 6/6/6/4 and 6/5/6/6 ring systems, respectively, while 3 and 4 are a pair of stereoisomeric matrine-acetophenone alkaloids with an unusual skeleton. Their structures were elucidated by means of spectroscopic methods and single-crystal X-ray diffraction. Hypothetical biogenetic pathways for 1-4 are proposed, and their antiviral activities are also discussed.
从苦豆子种子中分离得到了 4 种新型槐定碱类生物碱（1-4）。化合物 1 和 2 分别具有前所未有的 6/6/6/4 和 6/5/6/6 环系，而 3 和 4 则是一对具有不寻常骨架的立体异构槐定-苯乙酮类生物碱。通过光谱方法和单晶 X 射线衍射确定了它们的结构。提出了 1-4 的假设生物合成途径，并讨论了它们的抗病毒活性。
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