姜黄素与肺癌：microRNAs 的作用。

Curcumin and Lung Cancer: the Role of microRNAs.

机构信息

Department of Medicine, Unit of Geriatrics, Universita Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128 Rome. Italy.

Sabinsa Corporation, East Windsor, NJ. United States.

出版信息

Curr Pharm Des. 2017;23(23):3440-3444. doi: 10.2174/1381612823666170109144818.

DOI:10.2174/1381612823666170109144818

PMID:28067164

Abstract

BACKGROUND

Lung cancer is one of the most common types of cancer worldwide and is characterized by a poor prognosis, related to both late diagnosis and lack of effective treatments. In the last years, microRNAs (miRNAs) have been demonstrated to have an important role in tumor microenvironment and immune regulation. These RNAs can be categorized into tumor-suppressor genes, such as let-7 family and miR-34, and oncogenes such as miR-221 and miR-222. Curcumin is a bioactive polyphenol that is documented to have promising anticancer activity, and to be well tolerated in humans.

METHODS

The present review aims to gather available evidence on the involvement of mRNAs in the therapeutic effects of curcumin against lung cancer.

RESULTS

The anti-cancer properties of curcumin against lung cancer have been shown in both cellular and experimental models and are mediated by modulation of several molecular targets that regulate the expression of transcription factors, inflammatory cytokines, enzymes, growth factors, receptors, adhesion molecules, antiapoptotic proteins, and cell cycle proteins, leading to cell apoptosis, inhibition of cell proliferation and migration, and also chemo- and radio-sensitization of lung cancer cells. Recent studies have documented that pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215.

CONCLUSION

Further studies are necessary to explore this very promising field and the link between regulation of oncogenic and tumor-suppressive miRNAs and putative anti-cancer properties of curcumin.

摘要

背景

肺癌是全球最常见的癌症类型之一，其预后较差，这与晚期诊断和缺乏有效治疗有关。近年来，microRNAs（miRNAs）已被证明在肿瘤微环境和免疫调节中具有重要作用。这些 RNA 可分为肿瘤抑制基因，如 let-7 家族和 miR-34，以及癌基因，如 miR-221 和 miR-222。姜黄素是一种具有生物活性的多酚，具有有前途的抗癌活性，并且在人类中具有良好的耐受性。

方法

本综述旨在收集有关 mRNAs 参与姜黄素治疗肺癌的治疗效果的现有证据。

结果

姜黄素对肺癌的抗癌特性已在细胞和实验模型中得到证实，其介导机制是通过调节几个分子靶点来调节转录因子、炎症细胞因子、酶、生长因子、受体、粘附分子、抗凋亡蛋白和细胞周期蛋白的表达，从而导致细胞凋亡、抑制细胞增殖和迁移，以及肺癌细胞的化疗和放疗增敏。最近的研究表明，姜黄素在肺癌中的药理作用也通过调节几种 miRNAs 来介导，例如下调致癌 miR-21 和上调抑癌 miR-192-5p 和 miR-215。