Chen Ling, Li Jingyun, Li Qian, Yan Hui, Zhou Bei, Gao Yanli, Li Jun
Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China.
J Cell Biochem. 2017 Aug;118(8):1965-1968. doi: 10.1002/jcb.25873. Epub 2017 Apr 18.
Hypertrophic scarring (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Numerous studies have reported that non-coding RNAs (ncRNAs) including microRNAs (miRNAs, miRs) and long non-coding RNAs (lncRNAs) play important roles in HS formation. Exploring non-coding RNA-based methods to treat scar would be instrumental for devising new effective therapies against scar. J. Cell. Biochem. 118: 1965-1968, 2017. © 2017 Wiley Periodicals, Inc.
肥厚性瘢痕（HS）是一种由皮肤损伤后异常伤口愈合引起的纤维增生性疾病，其特征是细胞外基质过度沉积和成纤维细胞的侵袭性生长。许多研究报告称，包括微小RNA（miRNA，miR）和长链非编码RNA（lncRNA）在内的非编码RNA（ncRNA）在HS形成中起重要作用。探索基于非编码RNA的瘢痕治疗方法将有助于设计新的有效抗瘢痕疗法。《细胞生物化学杂志》118: 1965 - 1968，2017年。© 2017威利期刊公司。
