Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
RNA Biol. 2023 Jan;20(1):334-347. doi: 10.1080/15476286.2023.2223486.
Psoriasis is a chronic inflammatory skin disease characterized by skin infiltration of immune cells and abnormal epidermal thickening. The initial pathogenesis has not been fully elucidated. Non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs) and circular RNAs (circRNAs), comprise the majority of genome transcripts and are important influencers of gene transcription and post-transcription modulations. Emerging roles of ncRNAs in psoriasis were identified recently. This review summarizes the existing studies of psoriasis-related lncRNAs and circRNAs. A considerable proportion of the studied lncRNAs and circRNAs regulate keratinocyte mobility, such as keratinocyte proliferation and differentiation. Some lncRNAs and circRNAs are tightly related to keratinocyte inflammation reactions. Other reports demonstrated that they are also implicated in modulating immune cell differentiation, proliferation, and activation. This review might illuminate future psoriasis research and highlight that lncRNAs and circRNAs might act as therapeutic targets.
银屑病是一种慢性炎症性皮肤病，其特征是免疫细胞浸润和表皮异常增厚。其初始发病机制尚未完全阐明。非编码 RNA（ncRNA），包括长非编码 RNA（lncRNA）和环状 RNA（circRNA），构成了基因组转录本的大部分，是基因转录和转录后调控的重要影响因子。ncRNA 在银屑病中的作用最近被发现。本综述总结了与银屑病相关的 lncRNA 和 circRNA 的现有研究。相当一部分研究的 lncRNA 和 circRNA 调节角质形成细胞的迁移，如角质形成细胞的增殖和分化。一些 lncRNA 和 circRNA 与角质形成细胞炎症反应密切相关。其他报道表明，它们还参与调节免疫细胞的分化、增殖和激活。这篇综述可能会为未来的银屑病研究提供启示，并强调 lncRNA 和 circRNA 可能作为治疗靶点。
