Broch Kaspar, Leren Ida S, Saberniak Jørg, Ueland Thor, Edvardsen Thor, Gullestad Lars, Haugaa Kristina H
a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.
b Center for Heart Failure Research, Faculty of Medicine , University of Oslo , Oslo , Norway.
Biomarkers. 2017 May-Jun;22(3-4):367-371. doi: 10.1080/1354750X.2016.1278266. Epub 2017 Jan 24.
Diagnostic and prognostic evaluation remains challenging in arrhythmogenic right ventricular cardiomyopathy (ARVC). We measured plasma concentration of soluble ST2 (sST2) and assessed its association with right ventricular (RV) function and ventricular arrhythmias in patients with ARVC.
We included patients with ARVC and genotype positive relatives. Soluble ST2 was determined by ELISA. We assessed myocardial function by echocardiography including strain by speckle tracking technique.
We included 44 subjects (age 41 ± 15 years, 21 (48%) female). Soluble ST2 was associated with RV global strain (r = 0.44; p = 0.008), as well as with left ventricular (LV) function. Plasma levels of sST2 were higher in patients with ventricular arrhythmias than in patients without ventricular arrhythmias (35 ± 13 ng/mL vs. 26 ± 7 ng/mL, p = 0.009). The association between sST2 and ventricular arrhythmias remained significant even after adjusting for RV function (Wald = 5.2; p = 0.02).
Soluble ST2 is associated with RV and LV function in patients with ARVC. Soluble ST2 may aid in the determination of disease severity in ARVC.
致心律失常性右室心肌病（ARVC）的诊断和预后评估仍然具有挑战性。我们测定了可溶性ST2（sST2）的血浆浓度，并评估其与ARVC患者右心室（RV）功能和室性心律失常的关系。
我们纳入了ARVC患者及其基因阳性的亲属。通过酶联免疫吸附测定法（ELISA）测定可溶性ST2。我们通过超声心动图评估心肌功能，包括采用斑点追踪技术测定应变。
我们纳入了44名受试者（年龄41±15岁，21名（48%）女性）。可溶性ST2与右室整体应变相关（r = 0.44；p = 0.008），也与左心室（LV）功能相关。室性心律失常患者的sST2血浆水平高于无室性心律失常的患者（35±13 ng/mL对26±7 ng/mL，p = 0.009）。即使在调整右室功能后，sST2与室性心律失常之间的关联仍然显著（Wald = 5.2；p = 0.02）。
可溶性ST2与ARVC患者的右室和左室功能相关。可溶性ST2可能有助于确定ARVC的疾病严重程度。
