Kleibeuker J H, Jansen J B, Lamers C B
Department of Gastroenterology, University Hospital, Groningen, The Netherlands.
Digestion. 1989;43(1-2):60-5. doi: 10.1159/000199862.
The effects of the selective muscarinic M1-receptor antagonist pirenzepine and the nonselective muscarinic antagonist atropine on bombesin- and peptone-stimulated release of pancreatic polypeptide (PP) were studied in healthy subjects. To exclude any effect of changes in intraduodenal pH continuous intragastric titration was performed during all tests. Both pirenzepine (i.v. bolus 0.6 mg/kg) and atropine (i.v. bolus 15 micrograms/kg, followed by an infusion of 5 micrograms/kg.h) significantly reduced peptone-induced integrated mean rise of plasma PP from 28 +/- 5 to 8 +/- 4 and -2 +/- 5 pmol/l, respectively (n = 4). Both drugs also reduced bombesin-induced rise of plasma PP in all 4 subjects, from 27 +/- 12 to 6 +/- 4 and 7 +/- 1 pmol/l (0.05 less than p less than 0.1). It is concluded that cholinergic regulation of PP release is mediated mainly through muscarinic M1-receptors.
在健康受试者中研究了选择性毒蕈碱M1受体拮抗剂哌仑西平和非选择性毒蕈碱拮抗剂阿托品对蛙皮素和蛋白胨刺激的胰多肽（PP）释放的影响。为排除十二指肠内pH变化的任何影响，在所有试验期间均进行持续胃内滴定。哌仑西平（静脉推注0.6mg/kg）和阿托品（静脉推注15μg/kg，随后以5μg/kg·h输注）均使蛋白胨诱导的血浆PP综合平均升高分别从28±5显著降低至8±4和-2±5pmol/l（n = 4）。两种药物还使所有4名受试者中蛙皮素诱导的血浆PP升高，从27±12降至6±4和7±1pmol/l（0.05＜p＜0.1）。结论是PP释放的胆碱能调节主要通过毒蕈碱M1受体介导。
