Daniels Michael J D, Brough David
Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
Int J Mol Sci. 2017 Jan 5;18(1):102. doi: 10.3390/ijms18010102.
In the conventional pathway of protein secretion, leader sequence-containing proteins leave the cell following processing through the endoplasmic reticulum (ER) and Golgi body. However, leaderless proteins also enter the extracellular space through mechanisms collectively known as unconventional secretion. Unconventionally secreted proteins often have vital roles in cell and organism function such as inflammation. Amongst the best-studied inflammatory unconventionally secreted proteins are interleukin (IL)-1β, IL-1α, IL-33 and high-mobility group box 1 (HMGB1). In this review we discuss the current understanding of the unconventional secretion of these proteins and highlight future areas of research such as the role of nuclear localisation.
在蛋白质分泌的传统途径中，含有前导序列的蛋白质在经过内质网（ER）和高尔基体加工后离开细胞。然而，无前导序列的蛋白质也通过统称为非传统分泌的机制进入细胞外空间。非传统分泌的蛋白质在细胞和生物体功能（如炎症）中通常发挥着重要作用。在研究得最充分的炎症性非传统分泌蛋白质中，有白细胞介素（IL）-1β、IL-1α、IL-33和高迁移率族蛋白B1（HMGB1）。在本综述中，我们讨论了目前对这些蛋白质非传统分泌的理解，并强调了未来的研究领域，如核定位的作用。
