冠状动脉疾病和心脏综合征X患者的焦虑水平与心脏自主神经调节

Anxiety Level and Cardiac Autonomic Modulations in Coronary Artery Disease and Cardiac Syndrome X Patients.

作者信息

Lutfi Mohamed Faisal

机构信息

Department of Physiology - Faculty of Medicine and Health Sciences - Al-Neelain University, Khartoum, Sudan.

出版信息

PLoS One. 2017 Jan 9;12(1):e0170086. doi: 10.1371/journal.pone.0170086. eCollection 2017.

DOI:10.1371/journal.pone.0170086

PMID:28068419

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5222583/

Abstract

BACKGROUND

Anxiety and cardiac autonomic modulations (CAM) were thoroughly investigated in coronary artery disease (CAD) and cardiac syndrome X (CSX) patients worldwide, but not among Sudanese with similar pathology.

AIMS

To compare levels of anxiety and CAM between Sudanese patients with CSX and CAD.

MATERIALS AND METHODS

Anxiety was evaluated in 51 CAD and 26 CSX patients using Taylor Manifest anxiety score (TMAS) questionnaire while heart rate variability derived indices were used to assess CAM, namely natural logarithm of low frequency (LnLF), high frequency (LnHF) and LF/HF ratio (LnLF/HF).

RESULTS

Low anxiety levels were achieved by 6 (23.1%) and 9 (17.6%) patients with CSX and CAD respectively. High anxiety level was achieved by only one (3.8%) patient, who was suffering from CSX. TMAS was significantly higher in CSX (31.27 (21.97)) compared to CAD (21.86 (12.97), P = 0.021). However, abnormally increased anxiety was not associated with higher risk of CSX. LnLF, LnHF and LnLF/HF were comparable in CAD and CSX patients.

CONCLUSION

CSX and CAD patients showed comparable CAM. Although anxiety levels were higher in CSX compared to CAD, TMAS ≥ 35 failed to show significant association with CSX.

摘要

背景

全球范围内，对冠状动脉疾病（CAD）和心脏综合征X（CSX）患者的焦虑和心脏自主神经调节（CAM）进行了深入研究，但在患有类似病理的苏丹患者中尚未进行此类研究。

目的

比较苏丹CSX患者和CAD患者的焦虑水平和CAM。

材料与方法

使用泰勒显性焦虑量表（TMAS）问卷对51例CAD患者和26例CSX患者的焦虑情况进行评估，同时使用心率变异性衍生指标评估CAM，即低频自然对数（LnLF）、高频（LnHF）和低频/高频比值（LnLF/HF）。

结果

CSX患者中有6例（23.1%）、CAD患者中有9例（17.6%）焦虑水平较低。只有1例（3.8%）患有CSX的患者达到高焦虑水平。与CAD患者（21.86（12.97））相比，CSX患者的TMAS显著更高（31.27（21.97），P = 0.021）。然而，焦虑异常增加与CSX的较高风险无关。CAD患者和CSX患者的LnLF、LnHF和LnLF/HF相当。