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细分群体中的DNA多态性:两亚群模型中分离位点的期望数量

DNA polymorphism in a subdivided population: the expected number of segregating sites in the two-subpopulation model.

作者信息

Tajima F

机构信息

Department of Biology, Kyushu University, Fukuoka, Japan.

出版信息

Genetics. 1989 Sep;123(1):229-40. doi: 10.1093/genetics/123.1.229.

Abstract

Using the two subpopulation model, the expected numbers of segregating sites in a number of DNA sequences randomly sampled from a subdivided population were examined for several types of population subdivisions. It is shown that, in the case where the pattern of migration is symmetrical such as the finite island model, the expected number of segregating sites is independent of the migration rate when two or three DNA sequences are randomly sampled from the same subpopulation, but depends on the migration rate when more than three DNA sequences are sampled. It is also shown that the population subdivision can increase the amount of DNA polymorphism even in a subpopulation in some cases.

摘要

使用双亚群模型,针对若干类型的群体细分,研究了从一个细分群体中随机抽取的多个DNA序列中分离位点的预期数量。结果表明,在迁移模式对称的情况下,如有限岛屿模型,当从同一亚群中随机抽取两个或三个DNA序列时,分离位点的预期数量与迁移率无关,但当抽取的DNA序列超过三个时,则取决于迁移率。还表明,在某些情况下,群体细分甚至可以增加亚群内的DNA多态性。

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本文引用的文献

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Evolution in Mendelian Populations.孟德尔群体中的进化。
Genetics. 1931 Mar;16(2):97-159. doi: 10.1093/genetics/16.2.97.
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Evolutionary rate at the molecular level.分子水平的进化速率。
Nature. 1968 Feb 17;217(5129):624-6. doi: 10.1038/217624a0.
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Effective number of alleles in a subdivided population.细分群体中等位基因的有效数量。
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