厚叶大戟细胞毒性化合物的分离与鉴定
Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.
作者信息
Benmerache Abbes, Alabdul Magid Abdulmagid, Labed Amira, Kabouche Ahmed, Voutquenne-Nazabadioko Laurence, Hubert Jane, Morjani Hamid, Kabouche Zahia
机构信息
a Laboratoire d'Obtention des Substances Thérapeutiques (LOST), Département de chimie , Université des frères Mentouri-Constantine , Constantine , Algeria.
b ICMR-UMR CNRS 7312 , Groupe Isolement et Structure , Reims , France.
出版信息
Nat Prod Res. 2017 Sep;31(18):2091-2098. doi: 10.1080/14786419.2016.1277345. Epub 2017 Jan 9.
A new phorbol-type diterpene ester, 4,20-dideoxy-4α-phorbol-12β-acetate-13α-isobutyrate, in addition to 11 known compounds were isolated from the latex and roots of Euphorbia clementei Boiss. Structure elucidation was performed by comprehensive 1D and 2D NMR analyses (H and C NMR, COSY, ROESY, HSQC and HMBC experiments), mass spectrometry (HR-ESI-MS) and by comparison with literature data. The inhibitory activity of all isolated compounds was evaluated against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines and seven of these compounds exhibited a weak cytotoxicity with IC values ranging from 40 to 97 μM.
从克莱门氏大戟的乳胶和根中分离出一种新的佛波醇型二萜酯，4,20-二脱氧-4α-佛波醇-12β-乙酸酯-13α-异丁酸酯，以及11种已知化合物。通过全面的一维和二维核磁共振分析（氢谱和碳谱、COSY、ROESY、HSQC和HMBC实验）、质谱（高分辨电喷雾电离质谱）并与文献数据比较进行结构解析。评估了所有分离化合物对早幼粒细胞白血病HL60和人红白血病K562细胞系的抑制活性，其中七种化合物表现出较弱的细胞毒性，IC值范围为40至97μM。
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