Krstić Gordana, Jadranin Milka, Schols Dominique, Claes Sandra, Tešević Vele, Mandić Boris, Milosavljević Slobodan, Wittine Karlo
University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11010 Belgrade, Serbia.
Department of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia.
Molecules. 2025 Mar 25;30(7):1452. doi: 10.3390/molecules30071452.
Five previously undescribed tigliane diterpenes (- and ), along with three known tiglianes (, and ) were isolated from the root extract of using chromatographic techniques. The structures of the isolated compounds were determined using spectroscopic techniques. The isolated compounds were tested for anti-HIV activity against HIV-1 NL4.3 and HIV-2 ROD strains. Two derivatives ( and ) exhibited significant anti-HIV activity, with IC values ranging from 1.10 to 7.47 µM. This study highlights the potential of root as a source of novel bioactive tigliane derivatives, warranting further investigation for possible use in HIV treatment.
通过色谱技术从[植物名称]的根提取物中分离出了5种先前未描述的大戟烷二萜（-和），以及3种已知的大戟烷（、和）。使用光谱技术确定了分离出的化合物的结构。对分离出的化合物针对HIV-1 NL4.3和HIV-2 ROD毒株进行了抗HIV活性测试。两种衍生物（和）表现出显著的抗HIV活性，IC值范围为1.10至7.47μM。这项研究突出了[植物名称]根作为新型生物活性大戟烷衍生物来源的潜力，值得进一步研究其在HIV治疗中的可能用途。
