Nichols John
1 South West Thames Faculty, Royal College of General Practitioners, London, UK; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Nutr Health. 2017 Mar;23(1):13-15. doi: 10.1177/0260106016686094. Epub 2017 Jan 10.
The theory that raised blood homocysteine is a major factor in the development of cardiovascular disease was initially rejected by the medical establishment. Trials of a treatment to lower homocysteine in moderately advanced disease have failed to show benefits (except in those not treated with anti-platelet drug), but there is mounting evidence for a role in treatment of very early disease and as a preventive strategy. Recent evidence has shown that lowering of high blood homocysteine significantly slows cognitive decline and the brain shrinkage associated with Alzheimer's disease. This is a test that should be done more frequently by National Health Service (NHS) general practitioners and private practitioners.
血液中同型半胱氨酸水平升高是心血管疾病发展的主要因素这一理论最初遭到了医学界的拒绝。在中度晚期疾病中进行的降低同型半胱氨酸治疗试验未能显示出益处（除了未接受抗血小板药物治疗的患者），但越来越多的证据表明其在极早期疾病治疗及预防策略中发挥作用。最近的证据表明，降低高血液同型半胱氨酸水平可显著减缓与阿尔茨海默病相关的认知衰退和脑萎缩。英国国家医疗服务体系（NHS）的全科医生和私人执业医生应更频繁地进行这项检测。
