毒理学基础
Cornerstones of Toxicology.
作者信息
Hayes A Wallace, Dixon Darlene
机构信息
1 Harvard University, Cambridge, Massachusetts, USA.
2 Michigan State University, East Lansing, Michigan, USA.
出版信息
Toxicol Pathol. 2017 Jan;45(1):57-63. doi: 10.1177/0192623316675768.
The 35th Annual Society of Toxicologic Pathology Symposium, held in June 2016 in San Diego, California, focused on "The Basis and Relevance of Variation in Toxicologic Responses." In order to review the basic tenants of toxicology, a "broad brush" interactive talk that gave an overview of the Cornerstones of Toxicology was presented. The presentation focused on the historical milestones and perspectives of toxicology and through many scientific graphs, data, and real-life examples covered the three basic principles of toxicology that can be summarized, as dose matters (as does timing), people differ, and things change (related to metabolism and biotransformation).
2016年6月在加利福尼亚州圣地亚哥举行的第35届毒理病理学会年会聚焦于“毒理学反应变异的基础与相关性”。为了回顾毒理学的基本原理，会上进行了一场“宏观”互动讲座，概述了毒理学的基石。该讲座聚焦于毒理学的历史里程碑和观点，并通过众多科学图表、数据及实际生活例子阐述了毒理学的三个基本原理，可总结为：剂量很重要（时间也很重要）、个体存在差异、情况会发生变化（与代谢和生物转化相关）。
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