一例精神分裂症患者体内存在γ-氨基丁酸（GABA）受体抗体的病例。
A case of GABAR antibodies in schizophrenia.
作者信息
Haussleiter Ida S, Wandinger Klaus-Peter, Juckel Georg
机构信息
Department of Psychiatry, LWL University Hospital, Ruhr-University Bochum, Alexandrinen Str. 1, 44791, Bochum, Germany.
Institute of Laboratory Medicine, University of Luebeck, Luebeck, Germany.
出版信息
BMC Psychiatry. 2017 Jan 10;17(1):9. doi: 10.1186/s12888-016-1157-2.
BACKGROUND
In the last couple of years, schizophrenia was often discussed as autoimmune disease. Several antibodies were suspected, but so far there has been no proof of Gamma-aminobutyric acid (GABA) receptor antibodies in patients with schizophrenia.
CASE PRESENTATION
In this case report we present a 21-year old woman with schizophrenic symptoms, who showed anti-GABAB1 antibodies when screened by a vast recombinant neurology mosaic on Human Embryonic Kidney Cells 293 (HEK293) cells. The young woman presented with various psychotic symptoms as well as speech and motor ataxia, with the neurological signs starting in childhood.
CONCLUSION
A hypofunction of the GABAergic system is a possible cause of severe schizophrenic symptoms. Postmortem studies proved this hypothesis by showing dysfunctional GABAergic interneurons in various brain areas. Therefore one should always think of an immune-mediated pathogenesis as well memory impairment and behavioral changes co-occur with frequent seizures.
背景
在过去几年中，精神分裂症常被作为自身免疫性疾病进行讨论。人们怀疑有几种抗体，但到目前为止，尚未在精神分裂症患者中证实存在γ-氨基丁酸（GABA）受体抗体。
病例报告
在本病例报告中，我们介绍了一名患有精神分裂症症状的21岁女性，当通过在人胚肾细胞293（HEK293）细胞上进行的大量重组神经学镶嵌体筛查时，发现其存在抗GABAB1抗体。这位年轻女性出现了各种精神病症状以及言语和运动共济失调，神经系统症状始于童年。
结论
GABA能系统功能减退可能是严重精神分裂症症状的一个原因。死后研究通过显示不同脑区的GABA能中间神经元功能失调证实了这一假设。因此，当记忆障碍和行为改变与频繁发作同时出现时，人们应始终考虑免疫介导的发病机制。
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