Pevnitskiĭ L A, Guseva N G, Sibiriakova L G, Oskilko T G
Genetika. 1989 Jun;25(6):1101-7.
The distribution of HLA-A, B, C antigens has been studied in 40 patients with systemic scleroderma and in 200 healthy individuals (all Russians). An increased frequency of the antigens B35 and Cw4 has been discovered in patients, as compared with control. When analysing different clinical and common parameters, lung affection in the systemic scleroderma patients was found to be associated with the antigen A10 (58.9% versus 21% in control, RR = 5.22, EF = 0.476, Pc = 0.0363), the presence of antinuclear antibodies being associated with the antigen B35 (50% versus 17% in control, RR = 4.8, EF = 0.396, Pc = 0.0354). The association with the antigen B8 most commonly mentioned in the literature was characteristic of the patients with an earlier onset of the disease (under 30 years) and those with the rheumatoid factor. The patients having D-penicillamine-induced complications were found to have an increased frequency of the antigen B8, as compared with the alternative group of patients (2P = 0.0430).
对40例系统性硬化症患者和200名健康个体（均为俄罗斯人）的HLA - A、B、C抗原分布进行了研究。与对照组相比，发现患者中抗原B35和Cw4的频率增加。在分析不同的临床和一般参数时，发现系统性硬化症患者的肺部受累与抗原A10相关（对照组为21%，患者组为58.9%，相对危险度RR = 5.22，效应因子EF = 0.476，Pc = 0.0363），抗核抗体的存在与抗原B35相关（对照组为17%，患者组为50%，RR = 4.8，EF = 0.396，Pc = 0.0354）。文献中最常提到的与抗原B8的关联，在疾病发病较早（30岁以下）的患者以及有类风湿因子的患者中具有特征性。与另一组患者相比，发现有青霉胺诱导并发症的患者抗原B8频率增加（P = 0.0430）。
