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实施肺癌筛查:美国的经验

Implementing lung cancer screening: the US experience.

作者信息

Aberle D R

机构信息

Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.

出版信息

Clin Radiol. 2017 May;72(5):401-406. doi: 10.1016/j.crad.2016.12.003. Epub 2017 Jan 6.

DOI:10.1016/j.crad.2016.12.003
PMID:28069160
Abstract

The reduced lung cancer mortality observed with low-dose computed tomography (LDCT) screening in the National Lung Screening Trial (NLST) has led to annual screening in the United States as a covered benefit by both private insurers and the federal health insurance programme, the Centers for Medicare and Medicaid Services. Reimbursement for screening requires data submission to a federal registry on all individuals, whether privately or federally insured. Data must document individual patient eligibility as well as shared decision-making regarding the benefits and risks of LDCT screening, smoking cessation counselling, and the importance of annual screening. Beyond these requirements lie opportunities to maximise the benefits of screening in the radiology setting. Individuals eligible for screening account for a minority of those diagnosed with lung cancer in the US; the evidence needed to improve patient selection must be collected systematically for both screen-detected and incidentally detected lung nodules. Current nodule management and tracking guidelines reduce the false-positive rates observed in the NLST, but fall short in their ability to correctly classify nodules as benign or malignant. Smoking cessation is inadequately managed in most busy clinician practices. As a common nidus for tobacco-associated lung diseases, imagers are uniquely poised to collect the longitudinal data to better inform screening eligibility and to improve indeterminate nodule management, while maximising the setting of screening to motivate and provide smoking cessation. By re-engineering the notion of imaging practice, radiologists can be major contributors to lung cancer early detection and mortality reduction.

摘要

在国家肺癌筛查试验(NLST)中,低剂量计算机断层扫描(LDCT)筛查观察到肺癌死亡率降低,这使得美国将年度筛查作为一项涵盖福利,由私人保险公司和联邦医疗保险计划医疗保险和医疗补助服务中心提供。筛查报销要求向联邦登记处提交所有个人的数据,无论其是私人保险还是联邦保险。数据必须记录个体患者的资格,以及关于LDCT筛查的益处和风险、戒烟咨询以及年度筛查重要性的共同决策。除了这些要求之外,还有机会在放射学环境中最大化筛查的益处。在美国,符合筛查条件的个体占肺癌确诊患者的少数;必须系统收集改善患者选择所需的证据,用于筛查发现和偶然发现的肺结节。当前的结节管理和跟踪指南降低了NLST中观察到的假阳性率,但在将结节正确分类为良性或恶性的能力方面存在不足。在大多数繁忙的临床实践中,戒烟管理不足。作为烟草相关肺部疾病的常见病灶,影像科医生具有独特的优势来收集纵向数据,以更好地为筛查资格提供信息并改善不确定结节的管理,同时最大化筛查环境以激励并提供戒烟服务。通过重新设计影像实践的概念,放射科医生可以成为肺癌早期检测和降低死亡率的主要贡献者。

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