一种用于测量健全和脊髓损伤猫后肢地面反作用力的分体式跑步机的特性分析与验证
Characterization and validation of a split belt treadmill for measuring hindlimb ground-reaction forces in able-bodied and spinalized felines.
作者信息
Dimiskovski Marko, Scheinfield Richard, Higgin Dwight, Krupka Alexander, Lemay Michel A
机构信息
Department of Bioengineering, Temple University, Philadelphia, PA, United States.
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United States.
出版信息
J Neurosci Methods. 2017 Feb 15;278:65-75. doi: 10.1016/j.jneumeth.2017.01.002. Epub 2017 Jan 6.
BACKGROUND
The measurement of ground reaction forces (GRFs) in animals trained to locomote on a treadmill after spinal cord injury (SCI) could prove valuable for evaluating training outcomes; however, quantitative measures of the GRFs in spinal felines are limited.
NEW METHOD
A split belt treadmill was designed and constructed to measure the GRFs of feline hindlimbs during stepping. The treadmill consists of two independent treadmill assemblies, each mounted on a force plate. The design allows measurements of the vertical (F), fore-aft (F) and mediolateral (F) ground-reaction forces for both hindlimbs while the forelimbs are resting on a platform.
RESULTS
Static and dynamic noise tests revealed little to no noise at frequencies below 6Hz. Validation of the force plate measurements with a hand-held force sensor force showed good agreement between the two force readings. Peak normalized (to body mass) vertical GRFs for intact cats were 4.89±0.85N/kg for the left hindlimb and 4.79±0.97N/kg for the right. In comparison, trained spinalized cats peak normalized vertical GRFs were 2.20±0.94N/kg for the left hindlimb and 2.85±0.99N/kg for the right.
COMPARISON WITH OTHER EXISTING METHODS
Previous methods of measuring GRFs used stationary single force plates or treadmill mounted to single force plate. Using independent treadmills for each hindlimb allows measurement of the individual hindlimb's GRFs in spinalized cats following body-weight supported treadmill training.
CONCLUSIONS
The split belt force treadmill enables the simultaneous recording of ground-reaction forces for both hindlimbs in cats prior to spinalization, and following spinalization and body-weight-supported treadmill training (BWST).
背景
对于脊髓损伤（SCI）后在跑步机上训练行走的动物，测量地面反作用力（GRF）可能对评估训练效果很有价值；然而，脊髓损伤猫的GRF定量测量方法有限。
新方法
设计并制造了一种分体式跑步机，用于测量猫后肢在迈步过程中的GRF。该跑步机由两个独立的跑步机组件组成，每个组件安装在一个测力板上。这种设计允许在猫前肢 resting 在一个平台上时，测量两个后肢的垂直（F）、前后（F）和内外侧（F）地面反作用力。
结果
静态和动态噪声测试表明，在6Hz以下的频率几乎没有噪声。用手持式力传感器对测力板测量值进行验证，结果表明两个力读数之间具有良好的一致性。完整猫的左后肢峰值归一化（相对于体重）垂直GRF为4.89±0.85N/kg，右后肢为4.79±0.97N/kg。相比之下，经过训练的脊髓损伤猫的左后肢峰值归一化垂直GRF为2.20±0.94N/kg，右后肢为2.85±0.99N/kg。
与其他现有方法的比较
以前测量GRF的方法使用固定的单个测力板或安装在单个测力板上的跑步机。对每个后肢使用独立的跑步机，可以在体重支持的跑步机训练后测量脊髓损伤猫单个后肢的GRF。
结论
分体式测力跑步机能够同时记录猫在脊髓损伤前、脊髓损伤后以及体重支持的跑步机训练（BWST）后的两个后肢的地面反作用力。
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