Strulov Shachar Shlomit, Williams Grant R
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
Division of Oncology, Rambam Health Care Campus, Haifa, Israel.
Cancer Epidemiol Biomarkers Prev. 2017 Jan;26(1):13-16. doi: 10.1158/1055-9965.EPI-16-0439.
Body mass index (BMI) and simple counts of weight are easy and available tools in the clinic and in research. Recent studies have shown that cancer patients with a low normal BMI (or those with weight loss) have worse outcomes than obese patients. These results suggest that obesity has a protective effect and has been termed the "obesity paradox." In this commentary, we discuss hypothetical explanations and take a step beyond BMI or simple weights alone to present other useful and more specific body composition metrics, such as muscle tissue mass, visceral fat mass, and subcutaneous fat mass. Body composition is highly variable between individuals with significant differences seen between various races and ages. Therefore, it is critical to consider that patients with the exact same BMI can have significantly different body compositions and different outcomes. We encourage further studies to examine body composition beyond BMI and to use other body composition metrics to develop individualized treatments and intervention strategies. Cancer Epidemiol Biomarkers Prev; 26(1); 13-16. ©2017 AACR SEE ALL THE ARTICLES IN THIS CEBP FOCUS SECTION, "THE OBESITY PARADOX IN CANCER EVIDENCE AND NEW DIRECTIONS".
体重指数（BMI）和简单的体重计数是临床和研究中简便易得的工具。近期研究表明，BMI处于正常低值（或体重减轻）的癌症患者比肥胖患者的预后更差。这些结果表明肥胖具有保护作用，这一现象被称为“肥胖悖论”。在本评论中，我们讨论了一些假设性解释，并不仅仅局限于BMI或简单体重，而是介绍了其他有用且更具体的身体成分指标，如肌肉组织质量、内脏脂肪质量和皮下脂肪质量。个体之间的身体成分差异很大，不同种族和年龄之间也存在显著差异。因此，必须认识到BMI完全相同的患者可能具有截然不同的身体成分和预后。我们鼓励开展进一步研究，除BMI外，深入研究身体成分，并使用其他身体成分指标来制定个体化治疗和干预策略。《癌症流行病学、生物标志物与预防》；26(1)；13 - 16。©2017美国癌症研究协会 查看本CEBP聚焦板块“癌症中的肥胖悖论：证据与新方向”中的所有文章
