Yang Duo, Li Xiang, Qu Chao, Yi Jiayi, Gao Hai
Center for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Sci Rep. 2025 Jun 3;15(1):19359. doi: 10.1038/s41598-025-03333-9.
The effects of triglyceride-glucose (TyG) related indices on cardiometabolic disease (CMD) are still unclear. Our study aimed to investigate the relationship between the TyG-related indices and CMD risk among midlife women. This retrospective observational cohort study utilized data from the 2020 SWAN participants. The TyG index was computed as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Modified TyG indices were created by integrating TyG with body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression and receiver operating characteristic (ROC) analyses were conducted to assess the associations and predictive capacities of TyG and its related indices with CMD incidences. The mean age of participants was 45.7 years, comprising 420 (20.8%) Black, 184 (9.1%) Chinese, 225 (11.1%) Japanese, and 1191 (58.9%) Caucasian or Hispanic women. Over a 10-year follow-up, 837 women (41.4%) developed CMD. Compared to the lowest quartile, the adjusted hazard ratios (95% confidence intervals) for incident CMD in the highest quartile for TyG, TyG-BMI, TyG-WC, and TyG-WHtR were 1.78 (1.41-2.25), 3.26 (2.51-4.24), 3.13 (2.41-4.06), and 3.19 (2.47-4.12), respectively. The area under the ROC curve for modified TyG indices was significantly higher than that for the TyG index alone. Both the TyG and modified TyG indices were significantly associated with new-onset CMD, with modified TyG indices showing superior performance in identifying individuals at risk for CMD.
甘油三酯-葡萄糖（TyG）相关指标对心脏代谢疾病（CMD）的影响仍不明确。我们的研究旨在调查中年女性中TyG相关指标与CMD风险之间的关系。这项回顾性观察队列研究使用了2020年SWAN参与者的数据。TyG指数计算为Ln[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]。通过将TyG与体重指数（BMI）、腰围（WC）和腰高比（WHtR）相结合，创建了改良的TyG指数。进行多变量Cox比例风险回归和受试者工作特征（ROC）分析，以评估TyG及其相关指标与CMD发病率的关联和预测能力。参与者的平均年龄为45.7岁，其中包括420名（20.8%）黑人、184名（9.1%）中国人、225名（11.1%）日本人以及1191名（58.9%）白种人或西班牙裔女性。在10年的随访中，837名女性（41.4%）患上了CMD。与最低四分位数相比，TyG、TyG-BMI、TyG-WC和TyG-WHtR最高四分位数中发生CMD的调整后风险比（95%置信区间）分别为1.78（1.41-2.25）、3.26（2.51-4.24）、3.13（2.41-4.06）和3.19（2.47-4.12）。改良TyG指数的ROC曲线下面积显著高于单独的TyG指数。TyG和改良TyG指数均与新发CMD显著相关，改良TyG指数在识别CMD风险个体方面表现更优。
