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[伴有颈动脉和冠状动脉严重狭窄患者冠状动脉搭桥术中缺血性脑卒中共性因素]

[Common factors for ischemic cerebral stroke in coronary artery bypass grafting in patients with concomitant carotid and coronary artery severe stenosis].

作者信息

Huang Lei, Kuang Feng, Shan Zhonggui, Lai Yiquan, Guo Hongwei

机构信息

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Department of Cardiac Surgery, First affiliated Hospital of Xiamen University, Xiamen Fujian 361000, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Dec 28;41(12):1340-1344. doi: 10.11817/j.issn.1672-7347.2016.12.015.

DOI:10.11817/j.issn.1672-7347.2016.12.015
PMID:28070049
Abstract

To analyze two common factors for perioperative ischemic stroke in patients with concomitant carotid and coronary artery severe stenosis and to improve the therapeutic effect.
 Methods: A total of 44 patients with multi-vessel coronary artery disease combined with carotid stenosis, who admitted to the Department of Cardiac Surgery, the First Affiliated Hospital of Xiamen University from 2008 to 2014, were enrolled in this study. Among them, 32 cases were male, 12 cases was female. All patients received coronary artery bypass grafting after treatment of neck diseases. The surgical outcomes and follow-up results were analyzed retrospectively.
 Results: One patient received carotid endarterectomy suffered hemiplegia, whose symptoms were improved after positive clinical treatment. One patient suffered transient ischemic attack, and 5 patients displayed the cerebrovascular syndromes a week later after surgery. Twelve patients suffered nerve function damage 48 hours later after surgery. Nine patients received intra-aortic ballon pump, 1 patient received thoracotomy hemostasis, 3 patients suffered sternal dehiscence; 27 patients showed atrial fibrillation. Two patients died after surgery. The follow-up duration ranged from 1-7 years and the follow-up rate was 90%. The ischemic symptoms were improved in 44 patients. Six patients complained the recurrence of angina, but no abnormalities were found in coronary angiography or computed tomography angiography. One patient died of malignant tumor during the follow-up duration.
 Conclusion: For patients with concomitant carotid and coronary artery severe stenosis, it is more likely to suffer ischemic cerebral stroke. However, carotid stenosis is not the only factor, other key factors relevant to ischemic cerebral stroke shouldn't be ignored either.

摘要

分析合并颈动脉和冠状动脉严重狭窄患者围手术期缺血性卒中的两个常见因素,并提高治疗效果。方法:选取2008年至2014年在厦门大学附属第一医院心脏外科住院的44例多支冠状动脉疾病合并颈动脉狭窄患者纳入本研究。其中男性32例,女性12例。所有患者在颈部疾病治疗后均接受冠状动脉搭桥术。对手术结果和随访结果进行回顾性分析。结果:1例行颈动脉内膜切除术的患者出现偏瘫,经积极临床治疗后症状改善。1例患者发生短暂性脑缺血发作,5例患者在术后1周出现脑血管综合征。12例患者在术后48小时出现神经功能损害。9例患者接受主动脉内球囊反搏,1例患者接受开胸止血,3例患者发生胸骨裂开;27例患者出现心房颤动。2例患者术后死亡。随访时间为1至7年,随访率为90%。44例患者缺血症状均有改善。6例患者诉心绞痛复发,但冠状动脉造影或计算机断层血管造影未发现异常。1例患者在随访期间死于恶性肿瘤。结论:对于合并颈动脉和冠状动脉严重狭窄的患者,发生缺血性脑卒中的可能性更大。然而,颈动脉狭窄并非唯一因素,其他与缺血性脑卒中相关的关键因素也不应被忽视。

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