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食蟹猴（猕猴属）的超排卵反应取决于供体状态与所采用的超排卵方法之间的相互作用。

Superovulatory responses in cynomolgus monkeys (Macaca fascicularis) depend on the interaction between donor status and superovulation method used.

作者信息

Kim Ji-Su, Yoon Seung-Bin, Jeong Kang-Jin, Sim Bo-Woong, Choi Seon-A, Lee Sang-Il, Jin Yeung Bae, Song Bong-Seok, Lee Sang-Rae, Kim Sun-Uk, Chang Kyu-Tae

机构信息

National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea.

Department of Functional Genomics, University of Science and Technology, Daejeon 34113, Republic of Korea.

出版信息

J Reprod Dev. 2017 Apr 21;63(2):149-155. doi: 10.1262/jrd.2016-074. Epub 2017 Jan 9.

DOI:10.1262/jrd.2016-074
PMID:28070055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5401808/
Abstract

The current study was performed to investigate the effect of oocyte donor status, including age and body weight, on metaphase II (MII) oocyte recovery using two superovulation methods in cynomolgus monkeys. The use of Method A [recombinant gonadotrophin (75 IU/kg, 3 ×, 3-day intervals) and human chorionic gonadotropin (hCG)] led to great increases in ovary size and the mean number of MII oocytes retrieved in age- and body-weight-dependent manner; in contrast, both the parameters were similar in Method B [recombinant gonadotrophin (60 IU, twice daily, 6 days), recombinant gonadotropin and recombinant human luteinizing hormone (rhLH) (60 IU, twice daily, 3 days), and hCG]. Importantly, Method A showed maximal MII oocyte recovery rate in > 60-month-old or 4.5-5.0-kg female monkeys, whereas Method B was equally effective regardless of the donor age and body weight. These results indicate that superovulatory responses depend on the interaction between oocyte donor status and the superovulation method used in cynomolgus monkeys.

摘要

本研究旨在探讨卵母细胞供体状态（包括年龄和体重）对食蟹猴采用两种超排卵方法获取中期 II（MII）卵母细胞的影响。使用方法 A[重组促性腺激素（75 IU/kg，3 次，间隔 3 天）和人绒毛膜促性腺激素（hCG）]导致卵巢大小显著增加，且回收的 MII 卵母细胞平均数呈年龄和体重依赖性增加；相比之下，方法 B[重组促性腺激素（60 IU，每日两次，共 6 天）、重组促性腺激素和重组人促黄体生成素（rhLH）（60 IU，每日两次，共 3 天）以及 hCG]的这两个参数相似。重要的是，方法 A 在年龄大于 60 个月或体重 4.5 - 5.0 kg 的雌性食蟹猴中显示出最大的 MII 卵母细胞回收率，而方法 B 无论供体年龄和体重如何均同样有效。这些结果表明，超排卵反应取决于食蟹猴卵母细胞供体状态与所采用的超排卵方法之间的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/f08e84160c94/jrd-63-149-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/c7140ddc113c/jrd-63-149-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/7a8d55f5190b/jrd-63-149-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/7e998a675fa6/jrd-63-149-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/f0e1a0bd4291/jrd-63-149-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/f08e84160c94/jrd-63-149-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/c7140ddc113c/jrd-63-149-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/7a8d55f5190b/jrd-63-149-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/7e998a675fa6/jrd-63-149-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/f0e1a0bd4291/jrd-63-149-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d892/5401808/f08e84160c94/jrd-63-149-g005.jpg

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