Lofty Hala M, Marzouk Huda, Farag Yomna, Nabih Mohammad, Khalifa Iman A S, Mostafa Noha, Salah Ahmed, Rashed Laila, El Garf Kamal
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Int J Rheumatol. 2016;2016:7354018. doi: 10.1155/2016/7354018. Epub 2016 Dec 13.
. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. . The study enrolled seventy-one children with FMF. . SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. . High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.
血清淀粉样蛋白A（SAA）是在家族性地中海热（FMF）发作或其他炎症状态下检测到的一种急性期反应物。高SAA水平可能会增加淀粉样变性的风险。本研究的目的是测量一组患有家族性地中海热（FMF）的埃及儿童的血清淀粉样蛋白A（SAA）水平，并研究其各种相关性（如果存在的话）。本研究纳入了71名患有FMF的儿童。在78.9%的研究患者中SAA水平较高，平均为81.62±31.6mg/L，31%的患者C反应蛋白（CRP）呈阳性。SAA水平与任何人口统计学或临床表现之间均无显著相关性。V726A等位基因中高SAA更为常见（16.9%），其次是M694V等位基因（12.3%）。低剂量秋水仙碱治疗的患者中SAA水平升高更为常见。45%的患者对秋水仙碱治疗依从性差。在很大比例的埃及FMF儿童中，在最后一次FMF发作两周后检测到高SAA水平。这表明在无发作期亚临床炎症仍在持续，SAA可作为其标志物。
