Marks David F
Independent scholar.
Health Psychol Open. 2016 Mar 28;3(1):2055102916636907. doi: 10.1177/2055102916636907. eCollection 2016 Jan.
When eating control is overridden by hedonic reward, a condition of obesity dyshomeostasis occurs. Appetitive hedonic reward is a natural response to an obesogenic environment containing endemic stress and easily accessible and palatable high-energy foods and beverages. Obesity dyshomeostasis is mediated by the prefrontal cortex, amygdala and hypothalamic-pituitary-adrenal axis. The ghrelin axis provides the perfect signalling system for feeding dyshomeostasis, affect control and hedonic reward. Dyshomeostasis plays a central role in obesity causation, the addictions and chronic conditions and in persons with diverse bodies. Prevention and treatment efforts that target sources of dyshomeostasis provide ways of reducing adiposity, ameliorating the health impacts of addiction and raising the quality of life in people suffering from chronic stress.
当饮食控制被享乐性奖励压倒时，就会出现肥胖动态失衡的状况。食欲性享乐奖励是对含有地方性压力以及易于获取且美味的高能量食品和饮料的致胖环境的一种自然反应。肥胖动态失衡由前额叶皮层、杏仁核和下丘脑-垂体-肾上腺轴介导。胃饥饿素轴为进食动态失衡、情感控制和享乐奖励提供了完美的信号系统。动态失衡在肥胖成因、成瘾和慢性病以及不同体型的人群中起着核心作用。针对动态失衡根源的预防和治疗措施为减少肥胖、改善成瘾对健康的影响以及提高慢性应激患者的生活质量提供了途径。
