伊朗东南部人群中FAS A-670G多态性与子宫肌瘤风险的关联
Association of FAS A-670G Polymorphism and Risk of Uterine Leiomyoma in a Southeast Iranian Population.
作者信息
Mohammadpour-Gharehbagh Abbas, Salimi Saeedeh, Keshavarzi Farshid, Zakerian Sepideh, Sajadian Mojtaba, Mokhtari Mojgan
机构信息
Student Scientific Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Rep Biochem Mol Biol. 2016 Oct;5(1):51-55.
BACKGROUND
Uterine leiomyoma (UL) is a benign tumor of uterine smooth muscle that affects women in reproductive ages. FAS has an important role in initial stages of apoptosis. Previous studies have shown an association between the FAS gene and tumorigenesis. In the present study, we evaluated the relationship between FAS A-670G (rs 1800682) and UL risk.
METHODS
The FAS gene polymorphism of 155 women with UL and 157 healthy controls was analyzed by the polymerase chain reaction restriction fragment length polymorphism method.
RESULTS
The AA, AG, and GG genotype frequencies of the FAS A-670G polymorphism were respectively 37.4, 42.6, and 20% in women with UL, and 46, 42.6, and 11.5% in healthy controls. The risk of UL in women was 1.5-fold greater in GG-genotype women than in AA-genotype women. The G allele frequencies were 41% in women with UL and 33% in healthy controls and statistically different (P = 0.03).
CONCLUSION
The FAS polymorphism was associated with the risk of UL in a sample of Iranian women.
背景
子宫平滑肌瘤（UL）是一种影响育龄期女性的子宫平滑肌良性肿瘤。FAS在细胞凋亡的初始阶段起重要作用。先前的研究表明FAS基因与肿瘤发生之间存在关联。在本研究中，我们评估了FAS A-670G（rs 1800682）与UL风险之间的关系。
方法
采用聚合酶链反应-限制性片段长度多态性方法分析155例UL患者和157例健康对照者的FAS基因多态性。
结果
UL患者中FAS A-670G多态性的AA、AG和GG基因型频率分别为37.4%、42.6%和20%，健康对照者中分别为46%、42.6%和11.5%。GG基因型女性患UL的风险是AA基因型女性的1.5倍。UL患者的G等位基因频率为41%，健康对照者为33%，差异有统计学意义（P = 0.03）。
结论
在一组伊朗女性样本中，FAS多态性与UL风险相关。
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