Reimer R R, Hoover R, Fraumeni J F, Young R C
J Natl Cancer Inst. 1978 Nov;61(5):1195-7. doi: 10.1093/jnci/61.5.1195.
Follow-up surveys of patients with ovarian cancer revealed an increased risk of second primary cancers of the uterine corpus, colon, bladder, breast, and hematopoietic system. The excess risk or uterine corpus cancer was independent of therapy. The risk of colon cancer was increased in all treatment groups but was especially high among patients receiving radiation or chemotherapy. The predisposition to other neoplasms was limited to certain treatment groups: bladder cancer to irradiation, leukemia to chemotherapy, and lymphoma to either modality. The pattern of second neoplasms following ovarian cancer appears to be influenced by therapy as well as by common etiologic factors.
对卵巢癌患者的随访调查显示，子宫体、结肠、膀胱、乳腺和造血系统发生第二原发性癌症的风险增加。子宫体癌的额外风险与治疗无关。所有治疗组中结肠癌的风险均增加，但在接受放疗或化疗的患者中尤其高。其他肿瘤的易感性仅限于某些治疗组：膀胱癌与放疗有关，白血病与化疗有关，淋巴瘤与任何一种治疗方式有关。卵巢癌后的第二原发性肿瘤模式似乎受治疗以及共同病因因素的影响。
