Schenker J G, Levinsky R, Ohel G
Cancer. 1984 Jul 1;54(1):145-50. doi: 10.1002/1097-0142(19840701)54:1<139::aid-cncr2820540129>3.0.co;2-u.
The data of an epidemiologic study of multiple primary malignant neoplasms in breast cancer patients in Israel are presented. During the 18-year period of the study 12,302 cases of breast carcinoma were diagnosed, and, of these, 984 patients (8%) had multiple primary malignant tumors. Forty-seven of these patients developed two multiple primary cancers. A significantly higher than expected incidence of second primary cancers occurred at the following five sites: the opposite breast, salivary glands, uterine corpus, ovary, and thyroid. Cancers of the stomach and gallbladder were fewer than expected. Treatment of the breast cancer by irradiation was associated with an increased risk of subsequent cancers of lung and hematopoietic system. The prognosis was mainly influenced by the site and malignancy of the second primary cancer. The incidence of multiple primary malignancies justifies a high level of alertness to this possibility in the follow-up of breast cancer patients.
本文展示了以色列乳腺癌患者多原发性恶性肿瘤的流行病学研究数据。在18年的研究期间，共诊断出12302例乳腺癌病例，其中984例患者（8%）患有多原发性恶性肿瘤。这些患者中有47人发生了两种多原发性癌症。在以下五个部位发生的第二原发性癌症的发病率显著高于预期：对侧乳房、唾液腺、子宫体、卵巢和甲状腺。胃癌和胆囊癌的发病率低于预期。乳腺癌放疗与随后发生肺癌和造血系统癌症的风险增加有关。预后主要受第二原发性癌症的部位和恶性程度影响。多原发性恶性肿瘤的发病率表明，在乳腺癌患者的随访中，应对这种可能性保持高度警惕。
