Horhat Florin G, Gundogdu Fuat, David Laurentiu V, Boia Eugen S, Pirtea Laurentiu, Horhat Razvan, Cucui-Cozma Alexandru, Ciuca Ioana, Diaconu Mircea, Nitu Razvan, Licker Monica, Horhat Delia I, Rogobete Alexandru F, Moise Marius L, Tataru Calin
Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Biochem Genet. 2017 Jun;55(3):204-211. doi: 10.1007/s10528-016-9787-0. Epub 2017 Jan 9.
A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases. Moreover, identifying the genetic polymorphism in these patients can help in the implementation of a personalized intensive therapy scheme for every type of patient, based on its genotype.
发现高比例的重症患者会发展为急性呼吸窘迫综合征（ARDS）。多项研究报告了这些病例的高死亡率，这些病例最常与多器官功能障碍综合征相关。最近，人们做出了许多努力来评估和监测重症患者的ARDS。在这方面，对导致ARDS的基因多态性进行评估是一项挑战，并被视为未来的生物标志物。在重症患者中早期检测出导致ARDS的特定多态性基因可能会成为未来一种有用的工具，有助于降低这些病例的死亡率。此外，识别这些患者的基因多态性有助于根据其基因型为每种类型的患者实施个性化的强化治疗方案。
