根据白细胞介素6和白细胞介素8浓度评估，苯丙酮尿症并非炎症状态改变的风险因素。

Phenylketonuria is not a risk factor for changes of inflammation status as assessed by interleukin 6 and interleukin 8 concentrations.

作者信息

Mozrzymas Renata, Duś-Żuchowska Monika, Kałużny Łukasz, Wenska-Chyży Ewa, Walkowiak Jarosław

机构信息

Voivodeship Hospital, Wrocław, Poland.

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.

出版信息

Acta Sci Pol Technol Aliment. 2016 Apr-Jun;15(2):221-225. doi: 10.17306/J.AFS.2016.2.22.

DOI:10.17306/J.AFS.2016.2.22

PMID:28071012

Abstract

BACKGROUND

High oxidative stress and a reduced potential for free radical scavenging in phenylketonuria (PKU) patients, a phenomenon confirmed in a few studies, may lead to systemic chronic inflammation. The aim of this study was to compare the inflammation status, as assessed by interleukin 6 and interleukin 8 concentrations, in patients with PKU and in healthy controls.

METHODS

Twenty patients with classical PKU, aged 18-34 years and under dietary control, were enrolled in the study. The control group comprised of 20 healthy subjects matched for age and sex. Interleukin 6 and 8 levels were measured by enzyme-linked immunosorbent assay (ELISA) kits in all study participants.

RESULTS

IL-6 concentrations in the study group ranged from 0.74 pg/ml to 1.34 pg/ml. No significant differences were found between IL-6 concentration between the study group and the control group (p = 0.989). IL-8 concentrations ranged from 17.56 pg/ml to 20.87 pg/ml. The obtained results of IL-8 levels did not differ significantly between the study group and control group (p = 0.192). No significant correlation was observed between Phe blood levels and IL-6 or IL-8 concentrations in the study group (ρ respectively: -0.225, 0.177). In a multivariate analysis, neither IL-6 nor IL-8 concentrations were correlated with sex, age, BMI and Phe levels.

CONCLUSIONS

Phenylketonuria is not a risk factor for changes of inflammation status as assessed by IL-6 and IL-8 concentrations.

摘要

背景

苯丙酮尿症（PKU）患者存在高氧化应激以及自由基清除能力下降的情况，这一现象在一些研究中得到证实，可能会导致全身慢性炎症。本研究的目的是比较通过白细胞介素6和白细胞介素8浓度评估的PKU患者和健康对照者的炎症状态。

方法

本研究纳入了20名年龄在18 - 34岁且处于饮食控制下的经典PKU患者。对照组由20名年龄和性别相匹配的健康受试者组成。所有研究参与者均使用酶联免疫吸附测定（ELISA）试剂盒测量白细胞介素6和8水平。

结果

研究组中白细胞介素6浓度范围为0.74 pg/ml至1.34 pg/ml。研究组与对照组之间的白细胞介素6浓度未发现显著差异（p = 0.989）。白细胞介素8浓度范围为17.56 pg/ml至20.87 pg/ml。研究组与对照组之间白细胞介素8水平的所得结果无显著差异（p = 0.192）。研究组中苯丙氨酸血液水平与白细胞介素6或白细胞介素8浓度之间未观察到显著相关性（ρ分别为：-0.225，0.177）。在多变量分析中，白细胞介素6和白细胞介素8浓度均与性别、年龄、体重指数和苯丙氨酸水平无关。