Schröder S, Dralle H
Institut für Pathologie, Universität Hamburg, Germany.
Horm Metab Res Suppl. 1989;21:26-8.
Among 45 patients with medullary thyroid carcinoma, clinical parameters (age, sex, stage) and morphological findings (histological and immunocytochemical pattern, DNA content) were correlated with follow-up data. Prognosis was found not to be related to histological features or to immunoreactivity for a variety of hormonal and nonhormonal products typical of neoplastic C-cells. Instead, survival was significantly correlated to age, sex and stage of disease. The best prognosis was seen in women less than 40 years of age and revealing an early stage of disease. In addition, DNA parameters and the degree of aberrant epithelial Leu-M1 expression appeared to correspond to the outcome of disease in the majority of cases. A benign clinical course was twice as frequent among tumours of normal diploid DNA value compared to carcinomas of higher DNA content. Irrespective of other morphological and clinical features, local recurrences occurred 3 times and death resulting from tumour occurred 4.5 times more frequently among cases with marked Leu-M1 positivity in comparison to tumours with only slight or absent reactivity.
在45例甲状腺髓样癌患者中，将临床参数（年龄、性别、分期）和形态学表现（组织学和免疫细胞化学模式、DNA含量）与随访数据进行关联分析。结果发现，预后与组织学特征或对肿瘤性C细胞典型的多种激素和非激素产物的免疫反应性无关。相反，生存率与年龄、性别和疾病分期显著相关。预后最佳的是年龄小于40岁且疾病处于早期的女性。此外，在大多数病例中，DNA参数和异常上皮Leu-M1表达程度似乎与疾病转归相符。与DNA含量较高的癌相比，正常二倍体DNA值肿瘤的良性临床病程发生率高出两倍。无论其他形态学和临床特征如何，与反应轻微或无反应的肿瘤相比，Leu-M1显著阳性的病例局部复发发生率高3倍，肿瘤致死率高4.5倍。
