Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, PO Box 5825, Doha, Qatar.
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands.
Sci Rep. 2017 Jan 10;7:40263. doi: 10.1038/srep40263.
Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer's disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseline as well as in cognitively intact controls (n = 68). CSF total α-syn (t-α-syn) significantly increased in the AD group (p < 0.0001) compared to controls, while oligomeric- and phosphorylated-Ser129-α-syn did not change significantly. ROC analysis showed a sensitivity of 85% and a specificity of 84% (AUC = 0.88) in distinguishing AD from controls. T-α-syn levels correlated positively with tau species in AD group and negatively with baseline MMSE score. Our data support the added value of measurement of CSF α-syn species for further characterization of the CSF AD profile.
几项研究报告称，脑脊液α-突触核蛋白（α-syn）与阿尔茨海默病（AD）中的 tau 之间存在关联，并证明了 α-syn 在提高经典 AD 脑脊液生物标志物的诊断灵敏度/特异性方面的重要性。在本研究中，我们在一组基线时显示 AD 脑脊液特征的 AD 患者（n=225）和认知正常的对照组（n=68）中测量了不同的 α-syn 物种的脑脊液水平。与对照组相比，AD 组的脑脊液总 α-syn（t-α-syn）显著增加（p<0.0001），而寡聚体和磷酸化 Ser129-α-syn 没有显著变化。ROC 分析显示，区分 AD 与对照组的灵敏度为 85%，特异性为 84%（AUC=0.88）。AD 组的 t-α-syn 水平与 tau 物种呈正相关，与基线 MMSE 评分呈负相关。我们的数据支持测量脑脊液 α-syn 物种以进一步描述 CSF AD 图谱的附加价值。
