与阿尔茨海默病相比，帕金森病伴痴呆和路易体痴呆患者的脑脊液α-突触核蛋白寡聚物水平升高。
Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease.
机构信息
Department of Clinical Sciences, Lund University, Lund, Sweden ; Memory clinic, Skåne University Hospital, Lund, Sweden.
Department of Clinical Sciences, Lund University, Lund, Sweden ; Neurology clinic, Skåne University Hospital, Lund, Sweden.
出版信息
Alzheimers Res Ther. 2014 May 7;6(3):25. doi: 10.1186/alzrt255. eCollection 2014.
INTRODUCTION
The objective was to study whether α-synuclein oligomers are altered in the cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD), compared with age-matched controls.
METHODS
In total, 247 CSF samples were assessed in this study, including 71 patients with DLB, 30 patients with PDD, 48 patients with AD, and 98 healthy age-matched controls. Both total and oligomeric α-synuclein levels were evaluated by using well-established immunoassays.
RESULTS
The levels of α-synuclein oligomers in the CSF were increased in patients with PDD compared with the controls (P < 0.05), but not in patients with DLB compared with controls. Interestingly, the levels of α-synuclein oligomers in the CSF were also significantly higher in patients with PDD (P < 0.01) and DLB (P < 0.05) compared with patients with AD. The levels of CSF α-synuclein oligomers and the ratio of oligomeric/total-α-synuclein could distinguish DLB or PDD patients from AD patients, with areas under the curves (AUCs) of 0.64 and 0.75, respectively. In addition, total-α-synuclein alone could distinguish DLB or PDD patients from AD patients, with an AUC of 0.80.
CONCLUSIONS
The levels of α-synuclein oligomers were increased in the CSF from α-synucleinopathy patients with dementia compared with AD cases.
简介
本研究旨在探讨α-突触核蛋白寡聚体在痴呆患者（包括帕金森病伴痴呆[PDD]、路易体痴呆[DLB]和阿尔茨海默病[AD]）脑脊液（CSF）中是否发生改变，并与年龄匹配的对照组进行比较。
方法
本研究共评估了 247 例 CSF 样本，包括 71 例 DLB 患者、30 例 PDD 患者、48 例 AD 患者和 98 例健康年龄匹配的对照组。采用成熟的免疫测定法评估 CSF 中总α-突触核蛋白和寡聚体α-突触核蛋白的水平。
结果
与对照组相比，PDD 患者的 CSF 中α-突触核蛋白寡聚体水平升高（P<0.05），但 DLB 患者与对照组相比无差异。有趣的是，与 AD 患者相比，PDD（P<0.01）和 DLB（P<0.05）患者的 CSF 中α-突触核蛋白寡聚体水平也明显更高。CSF α-突触核蛋白寡聚体水平和寡聚体/总α-突触核蛋白的比值可将 DLB 或 PDD 患者与 AD 患者区分开来，曲线下面积（AUC）分别为 0.64 和 0.75。此外，仅总α-突触核蛋白即可将 DLB 或 PDD 患者与 AD 患者区分开来，AUC 为 0.80。
结论
与 AD 病例相比，伴有α-突触核蛋白病的痴呆患者的 CSF 中α-突触核蛋白寡聚体水平升高。
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