Sarkisov D S, Kolocolchicova E G, Varava B N, Tjurmin A V, Peclo M M
Institute of Surgery, USSR Academy of Medical Sciences, Moscow.
Hum Pathol. 1989 Nov;20(11):1048-56. doi: 10.1016/0046-8177(89)90222-0.
Hyperplastic intima in nonspecific aortoarteritis was investigated immunomorphologically and by means of electronmicroscopic autoradiography. The cellular composition of the involved vascular wall was studied by the method of alcohol-alkaline dissociation. The prevalence of elongated cells with side processes and stellate cells in thickened intima was shown. These cells are characterized by essentially intensive RNA synthesis and, according to the electron microscopic data, can be regarded as pericytes. A significant amount of capillaries and precapillaries in thickened intima was visualized. Distribution of laminin and type IV collagen coincided with localization of the basal membrane of the vasa vasorum and with that of microvessels growing in the intima. Considered together, these data suggest that pericytes that surround a capillary/precapillary network may play a significant role in the morphogenesis of vascular transformation in nonspecific aortoarteritis intimal thickening.
采用免疫形态学方法及电子显微镜放射自显影技术，对非特异性主动脉动脉炎中的增生性内膜进行了研究。采用乙醇 - 碱解离法研究了受累血管壁的细胞组成。结果显示，增厚内膜中存在带有侧突的细长细胞和星状细胞。这些细胞的特点是RNA合成基本活跃，根据电子显微镜数据，可视为周细胞。在增厚的内膜中可见大量毛细血管和毛细血管前微动脉。层粘连蛋白和IV型胶原的分布与滋养血管基底膜的定位以及在内膜中生长的微血管的定位一致。综合来看，这些数据表明，围绕毛细血管/毛细血管前微动脉网络的周细胞可能在非特异性主动脉动脉炎内膜增厚的血管形态发生中起重要作用。
