de Rosa G, Barra E, Gentile R, Boscaino A, Di Prisco B, Ayala F
Institute of Pathology, II Faculty of Medicine and Surgery, University of Naples, Italy.
Genitourin Med. 1989 Aug;65(4):252-4. doi: 10.1136/sti.65.4.252.
A rare case of verruciform xanthoma of the vulva is reported. Diagnosis was made possible by histopathological examination and immunohistochemical staining. Verruciform xanthomas generally occur in the oral cavity. To the best of our knowledge, this is the third reported case of the tumour located on the genital mucosa. Immunohistochemical study supported the histiocytic origin of the lesion. Clinically, verruciform xanthomas may mimic other verrucous lesions of the vulva, such as seborrhoeic keratosis, verruca simplex, condyloma acuminatum, verrucous carcinoma, or erythropasia of Queyrat, or conditions such as histiocytosis, cutaneous lipidosis, or granular cell myoblastoma. The characteristics that differentiate those conditions from verruciform xanthoma, which can be seen only on histology, are given.
本文报告了一例罕见的外阴疣状黄色瘤病例。通过组织病理学检查和免疫组化染色得以确诊。疣状黄色瘤通常发生于口腔。据我们所知，这是第三例报道的发生于生殖器黏膜的该肿瘤病例。免疫组化研究支持了该病变的组织细胞起源。临床上，疣状黄色瘤可能会与其他外阴疣状病变相似，如脂溢性角化病、单纯疣、尖锐湿疣、疣状癌或Queyrat增殖性红斑，或与组织细胞增多症、皮肤脂质沉积症或颗粒细胞瘤等疾病相似。文中给出了仅通过组织学才能观察到的、将这些疾病与疣状黄色瘤区分开来的特征。
