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Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.

作者信息

Park Jin-Sung, Kim Il-Kug, Han Sangyeul, Park Intae, Kim Chan, Bae Jeomil, Oh Seung Ja, Lee Seungjoo, Kim Jeong Hoon, Woo Dong-Cheol, He Yulong, Augustin Hellmut G, Kim Injune, Lee Doheon, Koh Gou Young

出版信息

Cancer Cell. 2017 Jan 9;31(1):157-158. doi: 10.1016/j.ccell.2016.12.009.

DOI:10.1016/j.ccell.2016.12.009
PMID:28073001
Abstract
摘要

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1
Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.通过激活Tie2和抑制Ang2实现肿瘤血管正常化可增强药物递送并产生有利的肿瘤微环境。
Cancer Cell. 2017 Jan 9;31(1):157-158. doi: 10.1016/j.ccell.2016.12.009.
2
Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.血管正常化通过 Tie2 激活和 Ang2 抑制增强药物传递并产生有利的肿瘤微环境。
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3
Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.血管生成素-2 在肿瘤模型中作为 Tie2 激动剂发挥作用，限制了 VEGF 抑制的效果。
Cancer Res. 2013 Jan 1;73(1):108-18. doi: 10.1158/0008-5472.CAN-12-2064. Epub 2012 Nov 13.
4
A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis.一种设计的血管生成素-2变体，五聚体COMP-Ang2，强烈激活Tie2受体并刺激血管生成。
Biochim Biophys Acta. 2009 May;1793(5):772-80. doi: 10.1016/j.bbamcr.2009.01.018. Epub 2009 Feb 10.
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Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.Tie1 调节血管生成素-2 对人淋巴管内皮细胞的 Tie2 激动作用。
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6
Fetoplacental regional variations in the expression of angiopoietin-1, angiopoietin-2, and Tie2 in normal-term and near-term pregnancies.足月和近足月妊娠中胎盘胎儿区域血管生成素-1、血管生成素-2和Tie2表达的区域差异
J Matern Fetal Neonatal Med. 2016 Nov;29(21):3421-8. doi: 10.3109/14767058.2015.1136282. Epub 2016 Mar 3.
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Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth.血管生成素-1对tie2受体的激活可增强肿瘤血管成熟并抑制鳞状细胞癌生长。
Am J Pathol. 2002 Apr;160(4):1381-92. doi: 10.1016/S0002-9440(10)62565-5.
8
Expressions of Angiopoietin-1, Angiopoietin-2, and Tie2 and their roles in rat renal allografts with chronic allograft nephropathy.血管生成素-1、血管生成素-2和Tie2的表达及其在慢性移植肾肾病大鼠同种异体肾移植中的作用。
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Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses.配体寡聚状态控制 Tie2 受体运输和血管生成素-2 特异性反应。
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Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth.具体靶向血管生成素-2 可抑制血管生成、Tie2 表达的单核细胞浸润和肿瘤生长。
Clin Cancer Res. 2011 Mar 1;17(5):1001-11. doi: 10.1158/1078-0432.CCR-10-2317. Epub 2011 Jan 13.

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