Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
Psychiatry Res. 2017 Mar;249:65-69. doi: 10.1016/j.psychres.2017.01.004. Epub 2017 Jan 2.
Patients with bipolar disorder (BD) are at high risk for developing cardiovascular diseases (CVDs) during aging process. However, investigations are lacking regarding the risk factors for CVDs specific to BD patients. The aim of this study was to examine the relationship between CVDs and traditional risk factors in association with the characteristics of BD in older age. Totally, we recruited 124 patients with BD-I (DSM-IV) who had at least one psychiatric admission and cardiologist-confirmed CVD diagnosis (ICD-9 code 401-414) at mean age of 61.7+4.9 years. Each case subject was matched with one BD-I patient without CVDs based on age, sex, and date of the most recent psychiatric admission (+2 years). Clinical data were obtained by retrospectively reviewing the medical record. A multiple logistic regression model showed that not only traditional risk factor (e.g., diabetes mellitus) but also non-traditional one associated with BD (e.g., first episode mania) significantly increased the risk of CVDs. Given the limitation of this cross-sectional study, longitudinal investigations are needed to elucidate the contributions of both traditional risk factors and the BD characteristics for CVD risk in patients with BD.
双相情感障碍（BD）患者在衰老过程中心血管疾病（CVDs）的风险很高。然而，针对 BD 患者特有的 CVD 风险因素的研究还很缺乏。本研究旨在探讨在老年时，CVDs 与传统危险因素之间的关系，并结合 BD 的特征。总共招募了 124 名符合 DSM-IV 诊断标准的 BD-I 患者（ICD-9 编码 401-414），这些患者至少有一次精神病住院治疗和心脏病专家确诊的 CVD 诊断，平均年龄为 61.7+4.9 岁。每位病例患者都根据年龄、性别和最近一次精神病住院治疗（+2 年）的日期与一名没有 CVD 的 BD-I 患者进行匹配。临床数据通过回顾病历获得。多因素逻辑回归模型显示，不仅传统的危险因素（如糖尿病），而且与 BD 相关的非传统因素（如首发躁狂）也显著增加了 CVDs 的风险。鉴于本横断面研究的局限性，需要进行纵向研究来阐明传统危险因素和 BD 特征对 BD 患者 CVD 风险的贡献。
