Villaescusa Patricia, Illescas María José, Valverde Laura, Baeta Miriam, Nuñez Carolina, Martínez-Jarreta Begoña, Zarrabeitia Maria Teresa, Calafell Francesc, de Pancorbo Marian M
BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
Laboratory of Genetics and Genetic Identification, University of Zaragoza, Spain.
Forensic Sci Int Genet. 2017 Mar;27:142-148. doi: 10.1016/j.fsigen.2016.12.013. Epub 2016 Dec 29.
The European paternal lineage R-DF27 has been proposed as a haplogroup of Iberian origin due to its maximum frequencies in the Iberian Peninsula. In this study, the distribution and structure of DF27 were characterized in 591 unrelated male individuals from four key populations of the north area of the Iberian Peninsula through the analysis of 12 Y-SNPs that define DF27 main sublineages. Additionally, Y-SNP allele frequencies were also gathered from the reference populations in the 1000 Genomes Project to compare and obtain a better landscape of the distribution of DF27. Our results reveal frequencies over 35% of DF27 haplogroup in the four North Iberian populations analyzed and high frequencies for its subhaplogroups. Considering the low frequency of DF27 and its sublineages in most populations outside of the Iberian Peninsula, this haplogroup seems to have geographical significance; thus, indicating a possible Iberian patrilineal origin of vestiges bearing this haplogroup. The dataset presented here contributes with new data to better understand the complex genetic variability of the Y chromosome in the Iberian Peninsula, that can be applied in Forensic Genetics.
欧洲父系谱系R-DF27因其在伊比利亚半岛具有最高频率而被认为是起源于伊比利亚的单倍群。在本研究中，通过对定义DF27主要亚谱系的12个Y-SNP进行分析，对来自伊比利亚半岛北部四个关键人群的591名无关男性个体的DF27分布和结构进行了表征。此外，还从千人基因组计划的参考人群中收集了Y-SNP等位基因频率，以进行比较并更好地了解DF27的分布情况。我们的结果显示，在所分析的四个伊比利亚北部人群中，DF27单倍群的频率超过35%，其亚单倍群频率也很高。考虑到DF27及其亚谱系在伊比利亚半岛以外的大多数人群中频率较低，这个单倍群似乎具有地理意义；因此，表明携带这个单倍群的遗迹可能起源于伊比利亚父系。本文提供的数据集为更好地理解伊比利亚半岛Y染色体复杂的遗传变异性提供了新数据，这些数据可应用于法医遗传学。
