University of Granada, Laboratory of Genetic Identification, Department of Legal Medicine, Toxicology and Physical Anthropology, Faculty of Medicine, PTS. Avd. Investigación 11, 18016, Granada, Spain.
University of Granada, Department of Biochemistry and Molecular Biology III and Inmunology, Faculty of Medicine, PTS. Avd. Investigación 11, 18016, Granada, Spain.
Sci Rep. 2019 Mar 26;9(1):5234. doi: 10.1038/s41598-019-41580-9.
The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele frequencies and haplogroup frequencies were also analyzed. By AMOVA and STRUCTURE analysis, the populations of the 3 provinces could be treated genetically as a single population. The most frequent haplogroup was R1b1b2 (58.22%). By network analysis of all individuals, we observed a distribution according to haplogroup assignment. To improve the characterization of GMA population, it was compared with those of North Africa, the Iberian Peninsula, and southern Europe. In our analysis of allele frequencies and genetic distances, the GMA population lay within the Spanish population group. Further, in the STRUCTURE analysis, there was no African component in the GMA population, confirming that, based on our genetic markers, the GMA population does not reflect any male genetic influence of the North African people. The presence of African haplogroups in the GMA population is irrelevant when their frequency is compared with those in other European populations.
对来自格拉纳达、马拉加和阿尔梅里亚省（GMA）的 146 名无亲缘关系的捐赠者居民的 17 个 Y 染色体短串联重复基因数据进行了分析，以确定前格拉纳达王国男性居民的遗传遗产。共确定了 139 个独特的单倍型。还分析了观察到的等位基因频率和单倍型频率。通过 AMOVA 和 STRUCTURE 分析，这 3 个省份的人群在遗传上可以被视为一个单一的群体。最常见的单倍型是 R1b1b2（58.22%）。通过对所有个体的网络分析，我们观察到根据单倍型分配的分布。为了更好地描述 GMA 人群，将其与北非、伊比利亚半岛和南欧的人群进行了比较。在我们对等位基因频率和遗传距离的分析中，GMA 人群属于西班牙人群。此外，在 STRUCTURE 分析中，GMA 人群中没有非洲成分，这证实了基于我们的遗传标记，GMA 人群不反映北非人的任何男性遗传影响。当与其他欧洲人群的频率进行比较时，GMA 人群中非洲单倍型的存在并不重要。
