Masoumi-Ardakani Yaser, Mahmoudvand Hossein, Mirzaei Amin, Esmaeilpour Khadijeh, Ghazvini Hamed, Khalifeh Solmaz, Sepehri Gholamreza
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Biomed Pharmacother. 2017 Mar;87:489-495. doi: 10.1016/j.biopha.2016.12.116. Epub 2017 Jan 7.
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition which develops in 6-8% of the general population. Current standard pharmacological treatments for PTSD cannot be widely used due to having various side effects. Nowadays, various pharmacological properties have been related to Elettaria cardamomum L. (family of Zingiberaceae). The present study aims to evaluate the efficacy of E. cardamomum methanolic extract on anxiety-like behavior in a rat model of PTSD. Adult male Wistar rats (200-250gr) were used in this study. The rats underwent single prolonged stress (SPS) or control and intraperitoneally received either saline or different dosages (200, 400, and 800mg/kg) of E. cardamomum methanolic extract before and after stress sessions. Moreover, open field, elevated plus-maze, and rotarod tests were used to evaluate locomotion and anxiety-like behavior in the rats. Findings demonstrated that E. Cardamomum methanolic extract, particularly at the dose of 400mg/kg, significantly (P<0.05) improved anxiety-like behavior in a rat model of PTSD, as examined by the open field, elevated plus-maze, and rotarod tests. Administration of E. cardamomum methanolic extract after stress might help to prevent the formation of anxiety-like behavior in the animals. However, further studies are requiredto clarify the exact mechanisms involved.
创伤后应激障碍（PTSD）是一种使人衰弱的精神疾病，在普通人群中的发病率为6%-8%。由于存在各种副作用，目前用于治疗PTSD的标准药物疗法无法广泛应用。如今，小豆蔻（姜科）已被证实具有多种药理特性。本研究旨在评估小豆蔻甲醇提取物对PTSD大鼠模型焦虑样行为的疗效。本研究使用成年雄性Wistar大鼠（200-250克）。大鼠经历单次长时间应激（SPS）或作为对照，在应激前后分别腹腔注射生理盐水或不同剂量（200、400和800毫克/千克）的小豆蔻甲醇提取物。此外，通过旷场试验、高架十字迷宫试验和转棒试验来评估大鼠的运动能力和焦虑样行为。研究结果表明，通过旷场试验、高架十字迷宫试验和转棒试验检测发现，小豆蔻甲醇提取物，尤其是400毫克/千克剂量，能显著（P<0.05）改善PTSD大鼠模型的焦虑样行为。应激后给予小豆蔻甲醇提取物可能有助于预防动物焦虑样行为的形成。然而，需要进一步研究以阐明其中的确切机制。
